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Blood pressure regulation: every adaptation is an integration?

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Abstract

This focused review serves to explore relevant issues in regard to blood pressure regulation and by doing so, provides the initial stimulus paper for the Thematic Review series “Blood Pressure Regulation” to be published in the European Journal of Applied Physiology over the coming months. In this introduction, we highlight how variable normal blood pressure can be and challenge the reader to take another look at some key concepts related to blood pressure regulation. We point out that there is frequently an underappreciated balance between peripheral vasodilation and systemic blood pressure regulation and ask the question: are changes in blood pressure, in effect, reasonable and integrated adaptations to the physiological challenge at hand? We conclude with the idea that blood pressure regulatory systems are both flexible and redundant; ensuring a wide variety of activities associated with life can be accompanied by a perfusion pressure that can serve multiple masters.

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References

  • Calbet JA, Jensen-Urstad M, van Hall G, Holmberg HC, Rosdahl H, Saltin B (2004) Maximal muscular vascular conductances during whole body upright exercise in humans. J Physiol 558:319–331

    Article  CAS  PubMed  Google Scholar 

  • Charkoudian N (2003) Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc 78:603–612

    Article  PubMed  Google Scholar 

  • Clausen JP (1977) Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev 57:779–815

    CAS  PubMed  Google Scholar 

  • Cowley AW (1992) Long-term control of arterial blood pressure. Physiol Rev 72(1):231–300

    PubMed  Google Scholar 

  • Cowley AW, DeClue JW (1976) Quantification of baroreceptor influence on arterial pressure changes seen in primary angiotension-induced hypertension in dogs. Circ Res 39:779–787

    Article  CAS  PubMed  Google Scholar 

  • Cowley AW Jr, Liard JF, Guyton AC (1973) Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32:564–576

    Article  PubMed  Google Scholar 

  • Crandall CG (2008) Heat stress and baroreflex regulation of blood pressure. Med Sci Sports Exerc 40:2063–2070

    Article  PubMed Central  PubMed  Google Scholar 

  • Fagius J, Wallin BG (1992) Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res 3:201–205

    Article  Google Scholar 

  • Halliwill JR, Buck TM, Lacewell AN, Romero SA (2013) Postexercise hypotension and sustained postexercise vasodilatation: what happens after we exercise? Exp Physiol 98:7–18

    Article  PubMed  Google Scholar 

  • Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J, Joyner MJ (2011) Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors. J Physiol 589:5285–5297

    Article  CAS  PubMed  Google Scholar 

  • Hart EC, Joyner MJ, Wallin BG, Charkoudian N (2012) Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors. J Physiol 590:2069–2079

    Article  CAS  PubMed  Google Scholar 

  • Holmes CL, Walley KR (2009) Vasoactive drugs for vasodilatory shock in ICU. Curr Opin Crit Care 15:398–402

    Article  PubMed  Google Scholar 

  • Joyner MJ (2006) Baroreceptor function during exercise: resetting the record. Exp Physiol 91:27–36

    Article  PubMed  Google Scholar 

  • Lassen NA (1974) Control of cerebral circulation in health and disease. Circ Res 34:749–760

    Article  CAS  PubMed  Google Scholar 

  • Lohmeier TE, Iliescu R (2012) Lowering of blood pressure by chronic suppression of central sympathetic outflow: insight from prolonged baroreflex activation. J Appl Physiol 113(10):1652–1658

    Article  PubMed  Google Scholar 

  • MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR (1985) Arterial blood pressure response to heavy resistance exercise. J Appl Physiol 58:785–790

    CAS  PubMed  Google Scholar 

  • Mark AL, Victor RG, Nerhed C, Wallin BG (1985) Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57:461–469

    Article  CAS  PubMed  Google Scholar 

  • Marshall RJ, Schirger A, Shepherd JT (1961) Blood pressure during supine exercise in idiopathic orthostatic hypotension. Circulation 24:76–81

    Article  CAS  PubMed  Google Scholar 

  • Melcher A, Donald DE (1981) Maintained ability of carotid baroreflex to regulate arterial pressure during exercise. Am J Physiol 24:H838–H849

    Google Scholar 

  • Millar-Craig MW, Bishop CN, Raftery EB (1978) Circadian variation of blood-pressure. Lancet 1:795–797

    Article  CAS  PubMed  Google Scholar 

  • Ogoh S, Fadel PJ, Nissen P, Jans O, Selmer C, Secher NH, Raven PB (2003) Baroreflex-mediated changes in cardiac output and vascular conductance in response to alterations in carotid sinus pressure during exercise in humans. J Physiol 550:317–324

    Article  CAS  PubMed  Google Scholar 

  • Paton JF, Dickinson CJ, Mitchell G (2009) Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing “Cushing’s mechanism”. Exp Physiol 94:11–17

    Article  CAS  PubMed  Google Scholar 

  • Raven PB, Potts JT, Shi X (1997) Baroreflex regulation of blood pressure during dynamic exercise. Exerc Sport Sci Rev 25:365–389

    Article  CAS  PubMed  Google Scholar 

  • Remensnyder JP, Mitchell JH, Sarnoff SJ (1962) Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptake. Circ Res 11:370–380

    Article  CAS  PubMed  Google Scholar 

  • Rowell LB (1992) Reflex control of the circulation during exercise. Int J Sports Med 13:S26–S27

    Article  Google Scholar 

  • Seals DR, Dinenno FA (2004) Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol 287:H1895–H1905

    Article  CAS  PubMed  Google Scholar 

  • Smit AA, Timmers HJ, Wieling W, Wagenaar M, Marres HA, Lenders JW, van Montfrans GA, Karemaker JM (2002) Long-term effects of carotid sinus denervation on arterial blood pressure in humans. Circulation 105:1329–1335

    Article  PubMed  Google Scholar 

  • Sundlöf G, Wallin BG (1977) The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272:383–397

    PubMed  Google Scholar 

  • Timmers HJ, Karemaker JM, Wieling W, Marres HA, Lenders JW (2003) Baroreflex control of muscle sympathetic nerve activity after carotid body tumor resection. Hypertension 42:143–149

    Article  CAS  PubMed  Google Scholar 

  • Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, Joyner MJ (2002) Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541:623–635

    Article  CAS  PubMed  Google Scholar 

  • Ursino M, Giannessi M, Frapparelli M, Magosso E (2009) Effect of cushing response on systemic arterial pressure. IEEE Eng Med Biol Mag 28:63–71

    Article  PubMed  Google Scholar 

  • Vanhoutte PM, Katusic ZS, Shepherd JT (1984) Vasopressin induces endothelium-dependent relaxations of cerebral and coronary, but not of systemic arteries. J Hypertens 2:S421–S422

    CAS  Google Scholar 

  • Volianitis S, Secher NH (2002) Arm blood flow and metabolism during arm and combined arm and leg exercise in humans. J Physiol 544:977–984

    Article  CAS  PubMed  Google Scholar 

  • Walgenbach SC, Donald DE (1983) Inhibition by carotid baroreflex of exercise-induced increases in arterial pressure. Circ Res 52:253–262

    Article  CAS  PubMed  Google Scholar 

  • Wieling W, Colman N, Krediet CT, Freeman R (2004) Nonpharmacological treatment of reflex syncope. Clin Auton Res 14(Suppl 1):62–70

    Article  PubMed  Google Scholar 

  • Wright JD, Hughes JP, Ostchega Y, Yoon SS, Nwankwo T (2011) Mean systolic and diastolic blood pressure in adults aged 18 and over in the United States, 2001–2008. Natl Health Stat Report 35(1–22):24

    Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Michael J. Joyner & Jacqueline K. Limberg

Authors
  1. Michael J. Joyner
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  2. Jacqueline K. Limberg
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Correspondence to Michael J. Joyner.

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Communicated by Nigel A. S. Taylor.

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Joyner, M.J., Limberg, J.K. Blood pressure regulation: every adaptation is an integration?. Eur J Appl Physiol 114, 445–450 (2014). https://doi.org/10.1007/s00421-013-2636-5

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  • DOI: https://doi.org/10.1007/s00421-013-2636-5

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