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Progression of primary open angle glaucoma in asymmetrically myopic eyes

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To compare progression of primary open angle glaucoma (POAG) in asymmetrically myopic eyes within the same subject and evaluate whether the degree of myopia is related to glaucoma progression.

Methods

POAG patients with asymmetric myopia (axial length [AXL] ≥24 mm in both eyes, and the AXL difference between the right and left eyes to be ≥0.5 mm) were included. Glaucoma progression was determined either by optic disc/retinal nerve fiber layer (RNFL) photographs or by serial visual field (VF) data. The progression rates of VF mean deviation (dB/year) and spectral domain optical coherence tomography measured RNFL thickness (μm/year) were compared between the more myopic eye (MME) and the less myopic eye (LME) within the same subject.

Results

A total of 55 patients (mean follow up period; 4.5 ± 1.0 years) were included. The mean AXL demonstrated a significant difference between MME and LME (26.3 ± 1.7 vs. 25.6 ± 1.7 mm; p = 0.036). The mean baseline VF MD (−3.8 ± 5.4 vs. −2.6 ± 4.7 dB; p = 0.21) and average RNFL thickness (77.5 ± 10.6 vs. 79.9 ± 12.3 μm; p = 0.36) did not differ between the MME and LME. Among the 55 patients, optic disc/RNFL photographic progression was noted in the MME in 15 patients, in the LME in 19 patients, and in both eyes in seven patients. VF progression was noted in the MME in seven patients, in the LME in seven patients, and in both eyes in four patients. The VF MD progression rates were −0.25 ± 0.34 dB/year in MME and −0.26 ± 0.34 dB/year in LME cases (p = 0.91). The mean progression rate of the average RNFL thickness also did not differ between the MME and LME (−0.59 ± 0.67 vs. -0.66 ± 0.72 μm/year, p = 0.68).

Conclusions

The degree of myopia was not associated with glaucoma progression when assessing the same patient using either the VF or optic disc/RNFL criteria in asymmetrically myopic patients.

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Authors and Affiliations

  1. Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea

    Min Kyung Song, Kyung Rim Sung, Seungbong Han, Jong Eun Lee, Joo Young Yoon, Ji Min Park & Ji Yun Lee

  2. Department of Applied Statistics, Gachon University, Seongnam-si, Gyeonggi-do, South Korea

    Seungbong Han

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  1. Min Kyung Song
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  2. Kyung Rim Sung
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  5. Joo Young Yoon
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Corresponding author

Correspondence to Kyung Rim Sung.

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Funding

This study was supported by a grant (2014–500) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Student Research Grant (2015) of University of Ulsan College of Medicine, Seoul, Korea, and the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology (NRF-2014R1A1A3A04051089). The sponsor had no role in the design or conduct of this research.

Conflict of interest

None of the authors have any affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Song, M.K., Sung, K.R., Han, S. et al. Progression of primary open angle glaucoma in asymmetrically myopic eyes. Graefes Arch Clin Exp Ophthalmol 254, 1331–1337 (2016). https://doi.org/10.1007/s00417-016-3332-z

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  • DOI: https://doi.org/10.1007/s00417-016-3332-z

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