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Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia

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Abstract

Profound white matter abnormalities have repeatedly been described in schizophrenia, which involve the altered expression of numerous oligodendrocyte-associated genes. Transcripts of the disrupted-in-schizophrenia 1 (DISC1) gene, a key susceptibility factor in schizophrenia, have recently been shown to be expressed by oligodendroglial cells and to negatively regulate oligodendrocyte differentiation and maturation. To learn more about the putative role(s) of oligodendroglia-associated DISC1 in schizophrenia, we analyzed the density of DISC1-immunoreactive oligodendrocytes in the fronto-parietal white matter in postmortem brains of patients with schizophrenia. Compared with controls (N = 12) and cases with undifferentiated/residual schizophrenia (N = 6), there was a significantly increased density of DISC1-expressing glial cells in paranoid schizophrenia (N = 12), which unlikely resulted from neuroleptic treatment. Pathophysiologically, over-expression of DISC1 protein(s) in white matter oligodendrocytes might add to the reduced levels of two myelin markers, 2′,3′-cyclic-nucleotide 3′-phosphodiesterase and myelin basic protein in schizophrenia. Moreover, it might significantly contribute to cell cycle abnormalities as well as to deficits in oligodendroglial cell differentiation and maturation found in schizophrenia.

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Abbreviations

CPZ:

Chlorpromazine

DAB:

3, 3′-diaminobenzidine

DISC1 :

Disrupted-in-schizophrenia 1

OLs:

Oligodendrocytes

n.a:

Not available

PBS:

Phosphate-buffered saline

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Acknowledgments

We are grateful to Bianca Jerzykiewicz and Gabriele Meyer-Lotz for excellent technical assistance.

Author Contributions

H-G. B. analyzed the data, researched, wrote, and edited the manuscript. E. J. analyzed the data. H. D. carried out statistical calculations and contributed to photography. C. M. carried out neuropathological studies. J. S wrote and edited the manuscript. B. B. wrote and edited the manuscript.

Role of the funding source

The study was funded by the Otto-von-Guericke-University Magdeburg.

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Authors and Affiliations

  1. Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany

    Hans-Gert Bernstein, Esther Jauch, Henrik Dobrowolny, Johann Steiner & Bernhard Bogerts

  2. Institute for Neuropathology, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany

    Christian Mawrin

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  1. Hans-Gert Bernstein
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Correspondence to Hans-Gert Bernstein.

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Bernstein, HG., Jauch, E., Dobrowolny, H. et al. Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. Eur Arch Psychiatry Clin Neurosci 266, 495–504 (2016). https://doi.org/10.1007/s00406-015-0640-y

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