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Reduced volume of the nucleus accumbens in heroin addiction

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Abstract

The neural mechanisms of heroin addiction are still incompletely understood, even though modern neuroimaging techniques offer insights into disease-related changes in vivo. While changes on cortical structure have been reported in heroin addiction, evidence from subcortical areas remains underrepresented. Functional imaging studies revealed that the brain reward system and particularly the nucleus accumbens (NAcc) play a pivotal role in the pathophysiology of drug addiction. The aim of this study was to investigate whether there was a volume difference of the NAcc in heroin addiction in comparison to healthy controls. A further aim was to correlate subcortical volumes with clinical measurements on negative affects in addiction. Thirty heroin-dependent patients under maintenance treatment with diacetylmorphine and twenty healthy controls underwent structural MRI scanning at 3T. Subcortical segmentation analysis was performed using FMRIB’s Integrated Registration and Segmentation Tool function of FSL. The State–Trait Anxiety Inventory and the Beck Depression Inventory were used to assess trait anxiety and depressive symptoms, respectively. A decreased volume of the left NAcc was observed in heroin-dependent patients compared to healthy controls. Depression score was negatively correlated with left NAcc volume in patients, whereas a positive correlation was found between the daily opioid dose and the volume of the right amygdala. This study indicates that there might be structural differences of the NAcc in heroin-dependent patients in comparison with healthy controls. Furthermore, correlations of subcortical structures with negative emotions and opioid doses might be of future relevance for the investigation of heroin addiction.

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Acknowledgments

This study was supported by the Swiss National Science Foundation (SNSF) (32003B-127544). We would like to acknowledge the infrastructural support of the Medical Image Analysis Centre, University Hospital Basel.

Conflict of interest

Till Sprenger served on advisory boards for Mitsubishi Pharma, Eli Lilly, Genzyme, Novartis, Biogen and Allergan. The other authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Psychiatry, University Psychiatric Clinics (UPK) of Basel, Basel, Switzerland

    Christian L. Seifert, Undine E. Lang, Christian G. Huber, Niklaus Denier, Marc Vogel, André Schmidt, Stefan Borgwardt & Marc Walter

  2. Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Christian L. Seifert

  3. Department of Neurology, University Hospital of Basel, Basel, Switzerland

    Stefano Magon & Till Sprenger

  4. Division of Neuroradiology, University Hospital of Basel, Basel, Switzerland

    Till Sprenger

  5. Medical Image Analysis Centre, University Hospital of Basel, Basel, Switzerland

    Till Sprenger, André Schmidt, Ernst-Wilhelm Radue & Stefan Borgwardt

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  1. Christian L. Seifert
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  2. Stefano Magon
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  3. Till Sprenger
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  10. Stefan Borgwardt
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  11. Marc Walter
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Correspondence to Christian L. Seifert.

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Seifert, C.L., Magon, S., Sprenger, T. et al. Reduced volume of the nucleus accumbens in heroin addiction. Eur Arch Psychiatry Clin Neurosci 265, 637–645 (2015). https://doi.org/10.1007/s00406-014-0564-y

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  • DOI: https://doi.org/10.1007/s00406-014-0564-y

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