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Genetic and environmental influences on obsessive-compulsive disorder

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Abstract

It is important to understand how genetic and environmental factors interact in the development of obsessive-compulsive disorder (OCD) in order to provide a cohesive model of the underlying pathogenic mechanisms. In this article, we provide an overview of the current knowledge of possible genetic and environmental contributions to the development of OCD. We consider the significant challenges for identifying risk factors for OCD as well as promising avenues for overcoming these obstacles in future research. In particular, we discuss the value of focusing on certain phenotypes, applying a dimensional approach, and investigating possible endophenotypes. We also describe innovative study designs that may be used in future research to explore the interaction between genetic vulnerability and environmental risk factors for OCD.

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References

  1. Abramowitz JS, Franklin ME, Schwartz SA, Furr JM (2003) Symptom presentation and outcome of cognitive-behavioral therapy for obsessive-compulsive disorder. J Consult Clin Psychol 71:1049–1057

    Article  PubMed  Google Scholar 

  2. Ackerman DL, Greenland S, Bystritsky A (1996) Use of receiver–operator characteristic (ROC) curve analysis to evaluate predictors of response to clomipramine therapy. Psychopharmacol Bull 32:157–165

    PubMed  CAS  Google Scholar 

  3. Ackerman DL, Greenland S, Bystritsky A, Morgenstern H, Katz RJ (1994) Predictors of drug treatment response in obsessive-compulsive disorder: multivariate analyses from a multi-center trial of clomipramine. J Clin Psychopharmacol 14:247–254

    Article  PubMed  CAS  Google Scholar 

  4. Albert U, Maina G, Ravizza L, Bogetto F (2002) An exploratory study on obsessive-compulsive disorder with and without a familial component: are there any phenomenological differences? Psychopathology 35:8–16

    Article  PubMed  Google Scholar 

  5. Alsobrook JP, Leckman JF, Goodman WK, Rasmussen SA, Pauls DL (1999) Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. Am J Med Genet (Neuropsychiatr Genet) 88:669–675

    Article  Google Scholar 

  6. Amir N, Freshman M, Ramsey B, Neary E, Brigidi B (2001) Thought–action fusion in individuals with OCD symptoms. Behav Res Ther 39:765–776

    Article  PubMed  CAS  Google Scholar 

  7. Arnold PD, Sicard T, Burroughs E, Richter MA, Kennedy JL (2006) Glutamate tansporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry 63:769–776

    Article  PubMed  CAS  Google Scholar 

  8. Atmaca M, Yildirim BH, Ozdemir BH, Aydin BA, Tezcan AE, Ozler AS (2006) Volumetric MRI assessment of brain regions in patients with refractory obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 30:1051–1057

    Article  PubMed  Google Scholar 

  9. Azzam A, Mathews CA (2003) Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am J Med Genet Part B (Neuropsychiatr Genet) 123B:64–69

    Article  Google Scholar 

  10. Ball SG, Baer L, Otto MW (1996) Symptom subtypes of obsessive-compulsive disorder in behavioral treatment studies: a quantitative review. Behav Res Ther 34:47–51

    Article  PubMed  CAS  Google Scholar 

  11. Bienvenu III OJ, Samuels J, Riddle MA, Hoehn-Saric R, Liang KY, Cullen BAM, Grados MA, Nestadt G (2000) The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol Psychiatry 48:287–293

    Article  PubMed  CAS  Google Scholar 

  12. Black DW, Monahan P, Gable J, Blum N, Clancy G, Baker P (1998) Hoarding and treatment response in 38 nondepressed subjects with obsessive-compulsive disorder. J Clin Psychiatry 59:420–425

    PubMed  CAS  Google Scholar 

  13. Blanes T, McGuire P (1997) Heterogeneity within obsessive-compulsive disorder: evidence for primary and neurodevelopmental subtypes. In: Keshavan MS, Murray RM (eds) Neurodevelopmental models of psychopathology. Cambridge University Press, London, pp 206–213

    Google Scholar 

  14. Bolton D, Eley TC, O’Connor TG, Perrin S, Rabe-Hesketh S, Rijsdijk F, Smith P (2006) Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins. Psychol Med 36:335–344

    Article  PubMed  Google Scholar 

  15. Brown TA, Campbell LA, Lehman CL, Grisham JR, Mancill RB (2001) Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. J Abnorm Psychol 110:585–599

    Article  PubMed  CAS  Google Scholar 

  16. Calamari JE, Wiegartz PS, Janeck AS (1999) Obsessive-compulsive disorder subgroups: a symptom-based clustering approach. Behav Res Ther 37:113–125

    Article  PubMed  CAS  Google Scholar 

  17. Cavallini MC, Bertelli S, Chiapparino D, Riboldi S, Bellodi L (2000) Complex segregation analysis of obsessive-compulsive disorder in 141 families of eating disorder probands, with and without obsessive-compulsive disorder. Neuropsychiatr Genet 96:384–391

    Article  CAS  Google Scholar 

  18. Cavallini MC, Di Bella D, Siliprandi F, Malchiodi F, Bellodi L (2002) Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. Am J Med Genet 114:347–353

    Article  PubMed  Google Scholar 

  19. Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006) Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry 163:1282–1284

    Article  PubMed  Google Scholar 

  20. Cromer KR, Schmidt NB, Murphy DL (2007) An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther 45:1683–1691

    Article  PubMed  Google Scholar 

  21. Cruz C, Camerena B, King N, Paez F, Sidenberg D, de la Fuente JR, Nicolini H (1997) Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. Neurosci Lett 231:1–4

    Article  PubMed  CAS  Google Scholar 

  22. Dickel DE, Veenstra-VanderWeele J, Chlu Blvens N, Wu X, Fischer DJ, Van Etten-Lee M, Himle JA, Leventhal BL, Cook EH, Hanna GL (2007) Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biol Psychiatry 61:322–329

    Article  PubMed  CAS  Google Scholar 

  23. Diniz JB, Rosario-Campos MC, Shavitt RG, Curi M, Hounie AG, Brotto SA, Miguel EC (2004) Impact of age of onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder. J Clin Psychiatry 65:22–27

    Article  PubMed  Google Scholar 

  24. Douglass HM, Moffitt TE, Dar R, McGee R, Silva P (1995) Obsessive-compulsive disorder in a birth cohort of 18-year-olds: prevalence and predictors. J Am Acad Child Adolesc Psychiatry 34:1424–1431

    Article  PubMed  CAS  Google Scholar 

  25. Eapen V, Pauls DL, Robertson MM (2006) The role of clinical phenotypes in understanding the genetics of obsessive-compulsive disorder. J Psychosom Res 61:359–364

    Article  PubMed  Google Scholar 

  26. Eichstedt JA, Arnold SL (2001) Childhood-onset obsessive-compulsive disorder: a tic related subtype of OCD? Clin Psychol Rev 21:137–157

    Article  PubMed  CAS  Google Scholar 

  27. Eley TC (2007) The genetic basis of anxiety disorders. In: Andrews G, Charney D, Sirovatka PJ, Regier DA (eds) Stress and fear circuitry disorders: refining the research agenda for DSM-V. American Psychiatric Association, Arlington (in press)

  28. Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D (1998) 5-HT2A promoter polymorphism-1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 351:1785–1786

    Article  PubMed  CAS  Google Scholar 

  29. Fontenelle LF, Marques C, Versiani M (2002) The effect of gender on the clinical features and therapeutic response in obsessive-compulsive disorder. Rev Bras Psiquiatr 24:7–11

    Google Scholar 

  30. Frankel M, Cummings JL, Robertson MM, Trimble MR, Hill MA, Benson DF (1986) Obsessions and compulsions in Gilles de la Tourette syndrome. Neurology 36:378–382

    PubMed  CAS  Google Scholar 

  31. Geller DA, Biederman J, Griffin S, Jones J, Lefkowitz TR (1996 ) Comorbidity of juvenile obsessive-compulsive disorder with disruptive behavior disorders. J Am Acad Child Adolesc Psychiatry 35:1637–1646

    Article  PubMed  CAS  Google Scholar 

  32. Geller DA, Biederman J, Jones J, Shapiro S, Schwartz S, Park KS (1998) Obsessive-compulsive disorder in children and adolescents: a review. Harv Rev Psychiatry 5:260–273

    Article  PubMed  CAS  Google Scholar 

  33. George MS, Trimble MR, Ring HA, Sallee FR, Robertson MM (2003) Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette’s syndrome. Am J Psychiatry 150:93–97

    Google Scholar 

  34. Gothelf D, Aharonovsky O, Horesh N, Carty T, Apter A (2004) Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders. Compr Psychiatry 45:192–198

    Article  PubMed  Google Scholar 

  35. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645

    Article  PubMed  Google Scholar 

  36. Grados MA, Riddle MA, Samuels J, Liang KY, Hoehn-Saric R, Bienvenu OJ III, Walkupa JT, Song DH, Nestadt G (2001) The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study. Biol Psychiatry 50:559–565

    Article  PubMed  CAS  Google Scholar 

  37. Grados MA, Walkup J, Walford S (2003) Genetics of obsessive-compulsive disorders: new findings and challenges. Brain Dev 25:S55–S61

    Article  PubMed  Google Scholar 

  38. Hajcak G, Simons RF (2002) Error-related brain activity in obsessive-compulsive undergraduates. Psychiatry Res 110:63–72

    Article  PubMed  Google Scholar 

  39. Hanna GL, Himle JA, Curtis GC, Gillespie BW (2005) A family study of obsessive-compulsive disorder with pediatric probands. Hum Hered 60:1–9

    Article  PubMed  Google Scholar 

  40. Hanna GL, Veenstra-VanderWeele J, Cox NJ, Boehnke M, Himle JA, Curtis GC, Leventhal BL, Cook EH (2002) Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 114:541–552

    Article  PubMed  Google Scholar 

  41. Hasler G, Pinto A, Greenberg BD, Samuels J, Fyer A, Pauls DL, Knowles JA, McCracken JT, Piacentini J, Riddle MA, Rauch SL, Rasmussen SA, WIllour VL, Grados MA, Cullen B, Bienvenu OJ III, Shugart YY, Liang KY, Rudolf HS, Wang Y, Ronquillo J, Nestadt G, Murphy DL (2007) Familiality of factor-analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD collaborative genetics study. Biol Psychiatry 61:617–625

    Article  PubMed  CAS  Google Scholar 

  42. Hemmings SMJ, Stein DJ (2006) The current status of association studies in obsessive-compulsive disorder. Psychiatr Clin N Am 29:411–444

    Article  Google Scholar 

  43. Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158:1568–1577

    Article  PubMed  CAS  Google Scholar 

  44. Hollander E (1993) Obsessive-compulsive spectrum disorders: an overview. Psychiatr Ann 23:355–358

    Google Scholar 

  45. Holmes A, Murphy DL, Crawley JN (2003) Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 54:953–959

    Article  PubMed  CAS  Google Scholar 

  46. Johannes S, Wieringa BM, Nager W, Rada D, Dengler R, Emrich HM, Munte TF, Dietrich DE (2001) Discrepant target detection and action monitoring in obsessive-compulsive disorder. Psychiatr Res Neuroimaging Sect 108:101–110

    Article  CAS  Google Scholar 

  47. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P, Ott J, Gogos JA (1999) Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45:1178–1189

    Article  PubMed  CAS  Google Scholar 

  48. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593–602

    Article  PubMed  Google Scholar 

  49. Kim SJ, Lee HS, Kim CH (2005) Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism. Neuropsychobiology 52:176–182

    Article  PubMed  CAS  Google Scholar 

  50. Kotb M, Norry-Teglund A, McGeer A, El-Sherbini H, Dorak MT, Kurshid A, Green K, Peeples J, Wade J, Thomson G, Schwartz B, Low DE (2002) An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 8:1398–1404

    Article  PubMed  CAS  Google Scholar 

  51. Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL (1997) Symptoms of obsessive-compulsive disorder. Am J Psychiatry 154:911–917

    PubMed  CAS  Google Scholar 

  52. Leckman JF, Kim YS (2006) A primary candidate gene for obsessive-compulsive disorder. Arch Gen Psychiatry 63:717–720

    Article  PubMed  Google Scholar 

  53. Leckman JF, Pauls DL, Heping Z, Rosario-Campos MC, Katsovitch L, Kidd KK, Pakstis AJ, Alsobrook JP, Robertson MM, McMahon WM, Walkup JT, van de Wetering BJM, King RA, Cohen DJ (2003) Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. Am J Med Genet 116B:60–68

    Article  PubMed  Google Scholar 

  54. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527–1531

    Article  PubMed  CAS  Google Scholar 

  55. Lochner C, du Toit PL, Zungu-Dirwayi N, Marais A, van Kradenburg J, Curr B, Seedat R, Niehaus DJH, Stein DJ (2002) Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls. Depress Anxiety 15:66–68

    Article  PubMed  Google Scholar 

  56. Lochner C, Hemmings SMJ, Kinnear CJ, Niehaus DJH, Nel D, Vorfield V, Moolman-Smook J, Seedat S, Stein D (2005) Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates. Compr Psychiatry 46:14–19

    Article  PubMed  Google Scholar 

  57. Lougee L, Perlmutter SJ, Nicolson R, Garver M, Swedo SE (2000) Psychiatric disorders in first-degree relatives of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). J Am Acad Child Adolesc Psychiatry 39:1120–1126

    Article  PubMed  CAS  Google Scholar 

  58. Mataix-Cols D (2006) Deconstructing obsessive-compulsive disorder: a multidimensional perspective. Curr Opin Psychiatry 19:84–89

    Article  PubMed  Google Scholar 

  59. Mataix-Cols D, Marks IM, Greist JH, Kobak KA, Baer L (2002) Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial. Psychother Psychosom 71:255–262

    Article  PubMed  Google Scholar 

  60. Mataix-Cols D, Rosario-Campos MC, Leckman JF (2005) A multidimensional model of obsessive-compulsive disorder. Am J Psychiatry 162:228–238

    Article  PubMed  Google Scholar 

  61. Mathews CA, Nievergelt CM, Azzam A, Garrido H, Chavira DA, Wessel J, Bagnarello M, Reus VI, Schork NJ (2007) Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding. Am J Med Genet Part B Neuropsychiatr Genet 144:174–182 (The official publication of the International Society of Psychiatric Genetics)

    Google Scholar 

  62. Miguel EC, Baer L, Coffey BJ, Rauch SL, Savage CR, O’Sullivan RL, Phillips K, Moretti C, Leckman JF, Jenike MA (1997) Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette’s syndrome. Br J Psychiatry 170:140–145

    Article  PubMed  CAS  Google Scholar 

  63. Miguel EC, Leckman JF, Rauch S, Rosario-Campos MC, Hounie AG, Mercadante MT, Chacon P, Pauls DL (2005) Obsessive-compulsive disorder phenotypes: implications for genetic studies. Molec Psychiatry 10:258–275

    Article  CAS  Google Scholar 

  64. Millet B, Chabane N, Delorme R, Leboyer M, Leroy S, Poirier M, Bourdel M, Mouren-Simeoni M, Rouillon F, Loo H, Kebs M (2003) Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. Am J Med Genet Part B Neuropsychiatr Genet 116B:55–59

    Article  Google Scholar 

  65. Moffitt TE, Caspi A, Rutter M (2005) Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62:473–481

    Article  PubMed  CAS  Google Scholar 

  66. Murray CJ, Lopez AD (1996) The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Harvard School of Public Health, Cambridge

    Google Scholar 

  67. Nestadt G, Samuels J, Riddle M, Bienvenu OJ, Liang KY, LaBuda M, Walkup JT, Grados MA, Hoehn-Saric R (2000) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57:358–363

    Article  PubMed  CAS  Google Scholar 

  68. Nicolini H, Cruz C, Paez F, Camarena B (1998) Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder. Gac Med Mex 134:521–527

    PubMed  CAS  Google Scholar 

  69. Pauls DL, Alsobrook JPI, Phill M, Goodman W, Rasmussen S, Leckman JF (1995) A family study of obsessive-compulsive disorder. Am J Psychiatry 152:76–84

    PubMed  CAS  Google Scholar 

  70. Pauls DL, Towbin KE, Leckman JF, Zahner GE, Cohen DJ (1986) Gilles de la Tourette’s syndrome and obsessive-compulsive disorder: evidence supporting a genetic relationship. Arch Gen Psychiatry 43:1177–1179

    PubMed  CAS  Google Scholar 

  71. Peterson BS, Leckman JF, Scahill L, Naftolin F, Keefe D, Charest NJ, Cohen DJ (1992) Steroid hormones and CNS sexual dimorphisms modulate symptom expression in Tourette’s syndrome. Psychoneuroendocrinology 17:553–563

    Article  PubMed  Google Scholar 

  72. Purcell S (2002) Variance components models for gene–environment interaction in twin analysis. Twin Res 5:554–571

    Article  PubMed  Google Scholar 

  73. Robertson MM, Trimble MR, Lees A (1988) The psychopathology of the Gilles de la Tourette: a phenomenological analysis. Br J Psychiatry 152:383–390

    Article  PubMed  CAS  Google Scholar 

  74. Rosario-Campos MC, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL (2005) A family study of early-onset obsessive-compulsive disorder. Am J Med Genet Part B (Neuropsychiatr Genet) 136B:92–97

    Article  Google Scholar 

  75. Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC (2001) Adults with early onset obsessive-compulsive disorder. Am J Psychiatry 158:1899–1903

    Article  PubMed  CAS  Google Scholar 

  76. Rosario-Campos MC, Miguel EC, Quatrano S, Chacon P, Ferrao Y, Findley D, Katsovitch L, Scahill L, King RA, Woody SR, Tolin DF, Hollander E, Kano Y, Leckman JF (2006) The dimensional Yale-Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Molec Psychiatry 11:495–504

    Article  CAS  Google Scholar 

  77. Rosenberg DR, Keshavan MS, O’Hearn KM, Dick EL, Bagwell WW, Seymour AB, Montrose DM, Pierri JN, Birmaher B (1997) Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry 54:824–830

    PubMed  CAS  Google Scholar 

  78. Salkovskis P (1985) Obsessive-compulsive problems: a cognitive behavioural analysis. Behav Res Ther 23:571–584

    Article  PubMed  CAS  Google Scholar 

  79. Samuels JF, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Pinto A, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Bienvenu OJ III, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G (2006) The OCD collaborative genetics study: methods and sample description. Am J Med Genet Part B (Neuropsychiatr Genet) 141:201–207

    Article  Google Scholar 

  80. Santangelo SL, Pauls DL, Goldstein JM, Faraone SV, Tsuang MT, Leckman JF (1994) Tourette’s syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder? J Am Acad Child Adolesc Psychiatry 33:795–804

    Article  PubMed  CAS  Google Scholar 

  81. Saxena S, Rauch SL (2000) Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin N Am 23:563–586

    Article  CAS  Google Scholar 

  82. Schindler KM, Richter MA, Kennedy JL, Pato MT, Pato CN (2000) Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. Am J Med Genet 96:721–724

    Article  PubMed  CAS  Google Scholar 

  83. Sheppard DM, Bradshaw JL, Purcell R, Pantelia C (1999) Tourette’s and comorbid syndromes: obsessive compulsive and attention deficit hyperactivity disorder. A common etiology? Clin Psychol Rev 19:531–552

    Article  PubMed  CAS  Google Scholar 

  84. Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Bienvenu OJ III, Hoehn-Saric R, Valle D, Liang KY, Riddle M, Nestadt G (2006) Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Molec Psychiatry 11:763–770

    Article  CAS  Google Scholar 

  85. Soriano-Mas C, Pujol J, Alonso P, Cardoner N, Menchon JM, Harrison BJ, Deus J, Vallejo J, Gaser C (2007) Identifying patients with OCD using whole-brain anatomy. NeuroImage 35:1028–1037

    Article  PubMed  Google Scholar 

  86. Stein DJ (2002) Obsessive-compulsive disorder. Lancet 360:397–405

    Article  PubMed  Google Scholar 

  87. Swedo SE (2002) Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Molec Psychiatry 7:S24–S25

    Article  Google Scholar 

  88. Swedo SE, Grant PJ (2005) Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry 46:227–234

    Article  PubMed  Google Scholar 

  89. Szeszko PR, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J, Banerjee SP, Moore GJ, Rosenberg DR (2004) Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings. Neuropsychopharmacology 29:826–832

    Article  PubMed  CAS  Google Scholar 

  90. van Grootheest DS, Cath DC, Beekman AT, Boomsma DI (2005) Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet 8:450–458

    PubMed  Google Scholar 

  91. Vasconcelos MS, Sampaio AS, Hounie AG, Akkerman F, Curi M, Lopes AC, Miguel EC (2007) Prenatal, perinatal, and postnatal risk factors in obsessive-compulsive disorder. Biol Psychiatry 61:301–307

    Article  PubMed  Google Scholar 

  92. Willour VL, Shugart YY, Samuels J, Grados MA, Cullen B, Bienvenu OJ III, Wang Y, Liang KY, Valle D, Hoehn-Saric R, Riddle M, Nestadt G (2004) Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. Am J Hum Genet 75:508–513

    Article  PubMed  CAS  Google Scholar 

  93. Winsberg ME, Cassic KS, Koran LM (1999) Hoarding in obsessive-compulsive disorder: a report of 20 cases. J Clin Psychiatry 60:591–597

    Article  PubMed  CAS  Google Scholar 

  94. Wu KD, Watson D (2005) Hoarding and its relation to obsessive-compulsive disorder. Behav Res Ther 43:897–921

    Article  PubMed  Google Scholar 

  95. Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR (2002) Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome. Am J Hum Genet 70:896–904

    Article  PubMed  CAS  Google Scholar 

  96. Zohar AH, Gross-Isseroff R, Hermesh H, Weizman A (1999) Is there sexual dimorphism in obsessive-compulsive disorder? Neurosci Biobehav Rev 23:845–849

    Article  PubMed  CAS  Google Scholar 

  97. Zohar AH, Ratzoni G, Pauls DL, Apter A, Bleich A, Kron S, Rappaport M, Weizman A, Cohen DJ (1992) An epidemiological study of obsessive-compulsive disorder and related disorders in Israeli adolescents. J Am Acad Child Adolesc Psychiatry 31:1057–1061

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This manuscript was supported by a Postdoctoral Fellowship with the School of Psychiatry, University of New South Wales and by the National Health and Medical Research Council (Program Grant 350833).

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Authors and Affiliations

  1. School of Psychology, University of New South Wales, Sydney, NSW, 2052, Australia

    Jessica R. Grisham Ph.D.

  2. School of Psychiatry, University of New South Wales, Sydney, NSW, Australia

    Tracy M. Anderson Ph.D. & Perminder S. Sachdev M.D., Ph.D., FRANZCP

  3. Neuropsychiatric Institute, Prince of Wales Hospital, Little Bay, NSW, Australia

    Perminder S. Sachdev M.D., Ph.D., FRANZCP

  4. Primary Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia

    Perminder S. Sachdev M.D., Ph.D., FRANZCP

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  1. Jessica R. Grisham Ph.D.
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Grisham, J.R., Anderson, T.M. & Sachdev, P.S. Genetic and environmental influences on obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosc 258, 107–116 (2008). https://doi.org/10.1007/s00406-007-0789-0

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