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ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system

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References

  1. Chan JK, Lamant L, Algar E et al (2008) ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood 112(7):2965–2968. https://doi.org/10.1182/blood-2008-03-147017

    Article  CAS  PubMed  Google Scholar 

  2. Chang KTE, Tay AZE, Kuick CH et al (2018) ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Mod Pathol 32(5):598–608. https://doi.org/10.1038/s41379-018-0168-6

    Article  PubMed  Google Scholar 

  3. Huang H, Gheorghe G, North PE, Suchi M (2018) Expanding the phenotype of ALK-positive histiocytosis: a report of 2 cases. Pediatr Dev Pathol 21(5):449–455. https://doi.org/10.1177/1093526617740784

    Article  PubMed  Google Scholar 

  4. Louis DN, Ohgaki H, Wiestler OD et al (2016) WHO Classification of Tumours of the Central Nervous System (revised 4th edition). International Agency for Research on Cancer (IARC), Lyon, France

  5. Kline CN, Joseph NM, Grenert JP et al (2017) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-oncology 19(5):699–709. https://doi.org/10.1093/neuonc/now254

    Article  CAS  PubMed  Google Scholar 

  6. Diamond EL, Durham BH, Haroche J et al (2016) Diverse and targetable kinase alterations drive histiocytic neoplasms. Cancer Discov 6(2):154–165. https://doi.org/10.1158/2159-8290.CD-15-0913

    Article  CAS  PubMed  Google Scholar 

  7. Estrada-veras JI, O'brien KJ, Boyd LC et al (2017) The clinical spectrum of Erdheim–Chester disease: an observational cohort study. Blood Adv 1(6):357–366. https://doi.org/10.1182/bloodadvances.2016001784

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yoshihara K, Wang Q, Torres-garcia W et al (2015) The landscape and therapeutic relevance of cancer-associated transcript fusions. Oncogene 34(37):4845–4854. https://doi.org/10.1038/onc.2014.406

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

D.A.S is supported by NIH Director’s Early Independence Award (DP5 OD021403). We thank the staff of the UCSF Clinical Cancer Genomics Laboratory for assistance with genetic profiling.

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Correspondence to Arie Perry.

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Lucas, CH.G., Gilani, A., Solomon, D.A. et al. ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system. Acta Neuropathol 138, 335–337 (2019). https://doi.org/10.1007/s00401-019-02027-7

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