Skip to main content
SpringerLink
Log in

Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H et al (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. https://doi.org/10.1016/j.bbrc.2006.10.093

    Article  PubMed  Google Scholar 

  2. Mackenzie IR, Neumann M (2017) Reappraisal of TDP-43 pathology in FTLD-U subtypes. Acta Neuropathol 134:79–96. https://doi.org/10.1007/s00401-017-1716-8

    Article  CAS  PubMed  Google Scholar 

  3. Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E et al (2011) A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 122:111–113. https://doi.org/10.1007/s00401-011-0845-8

    Article  PubMed  PubMed Central  Google Scholar 

  4. Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT et al (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130–133. https://doi.org/10.1126/science.1134108

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Yasushi Nishihira and Tamar Gefen contributed equally to the work.

Authors and Affiliations

  1. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Yasushi Nishihira MD, PhD, Qinwen Mao, Christina Appin, Missia Kohler, Jamie Walker & Eileen H. Bigio

  2. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Tamar Gefen PhD, Emily Rogalski & Sandra Weintraub

  3. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Tamar Gefen PhD, Qinwen Mao, Alfred Rademaker, Emily Rogalski, Sandra Weintraub, Changiz Geula, M-Marsel Mesulam & Eileen H. Bigio

  4. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Rosa Rademakers

  5. Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Alfred Rademaker

  6. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    M-Marsel Mesulam

Authors
  1. Yasushi Nishihira MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tamar Gefen PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qinwen Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christina Appin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Missia Kohler
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jamie Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rosa Rademakers
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alfred Rademaker
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Emily Rogalski
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sandra Weintraub
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Changiz Geula
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M-Marsel Mesulam
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Eileen H. Bigio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eileen H. Bigio.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nishihira, Y., Gefen, T., Mao, Q. et al. Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes. Acta Neuropathol 138, 167–169 (2019). https://doi.org/10.1007/s00401-019-02024-w

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-019-02024-w

Search

Navigation