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Fatal intracranial hemorrhage from brain AVM in a 7-week-old infant: case report and recent literature review

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Abstract

Brain arteriovenous malformations (AVMs) are vascular abnormalities that typically present with spontaneous hemorrhage, seizure, or as a mass lesion. Pediatric brain AVMs are rarely diagnosed but carry a higher rate of rupture. We report a 7-week-old infant with rapid fatal intracranial hemorrhage from an undiagnosed brain. AVM confirmed at autopsy. Literature review on pediatric patients who had acute death caused by previously undiagnosed brain AVM from 1992 to 2018 revealed that cerebellum is the most frequent location of such AVMs, followed by thalamus. All the children had extensive intracranial hemorrhage that led to their deterioration despite surgical intervention.

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Author notes

  1. Xinhai Robert Zhang and Ting Zhang contributed equally to this work.

Authors and Affiliations

  1. Section of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Xinhai Robert Zhang & Harry V. Vinters

  2. Department of Pathology, Rush University Medical Center, Chicago, IL, USA

    Xinhai Robert Zhang

  3. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Ting Zhang & Harry V. Vinters

  4. Department of Pediatrics, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA

    Leanna L. Huard

  5. Department of Radiological Science, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA

    J. Pablo Villablanca

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  1. Xinhai Robert Zhang
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  2. Ting Zhang
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Correspondence to Harry V. Vinters.

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Zhang, X.R., Zhang, T., Huard, L.L. et al. Fatal intracranial hemorrhage from brain AVM in a 7-week-old infant: case report and recent literature review. Childs Nerv Syst 36, 1563–1568 (2020). https://doi.org/10.1007/s00381-020-04515-8

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  • DOI: https://doi.org/10.1007/s00381-020-04515-8

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