Skip to main content
SpringerLink
Log in

Genetic and physical mapping of the mouse host resistance locus Lgn1

  • Short Communication
  • Published:
Mammalian Genome Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Beckers M-C, Yoshida S-I, Morgan K, Skamene E, Gros P (1995) Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mamm Genome 6, 540–545

    Article  PubMed  CAS  Google Scholar 

  • Beckers M-C, Ernst E, Diez E, Morissette C, Gervais F, Hunter K, Housman D, Yoshida S-I, Skamene E, Gros P (1997) High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgnl. Genomics 39, 254–263

    Article  PubMed  CAS  Google Scholar 

  • Berger KH, Isberg RR (1993) Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol 7, 7–19

    Article  PubMed  CAS  Google Scholar 

  • Brieland J, Freeman P, Kunkel R, Chrisp C, Hurley M, Fantone J, Engleberg C (1994) Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires’ disease. AJP 145, 1537–1546

    PubMed  CAS  Google Scholar 

  • Bussaglia E, Clermont O, Tizzano E, Lefebvre S, Burglen L, Cruaud C, Urtizberea JA, Colomer J, Munnich A, Baiget M (1995) A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients. Nature Genet 11, 335–337

    Article  PubMed  CAS  Google Scholar 

  • DiDonata CJ, Chen X-N, Noya D, Korenberg JR, Nadeau JH, Simard LR (1997a) Cloning, characterization and copy number of the murine Survival Motor Neuron gene: homolog of the Spinal Muscular Atrophy-determining gene. Genome Res 7, 339–352

    Google Scholar 

  • DiDonato CJ, Nadeau JH, Simard LR (1997b) The mouse neuronal apoptosis inhibitor protein gene maps to a conserved region of mouse Chromosome 13. Mamm Genome 8, 222

    Article  PubMed  CAS  Google Scholar 

  • Dietrich WF, Damron DM, Isberg RR, Lander ES, Swanson MS (1995) Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics 26, 443–450

    Article  PubMed  CAS  Google Scholar 

  • Fraser DW, Tsai TR, Orenstein W (1977) Legionnaire’ disease. Description of an epidemic of pneumonia. N Engl J Med 297, 1189–11971

    PubMed  CAS  Google Scholar 

  • Fujio H, Yoshida S, Miyamoto H, Mitsuyama M, Mizuguchi Y (1992) Investigation of the role of macrophages and endogenous interferon-g in natural resistance of mice against Legionella pneumophila infection. FEMS Microbiol Immunol 89, 183–191

    Google Scholar 

  • Glick TH, Gregg MB, Berman B, Mallison GF, Rhodes WW Jr, Kassanoff L (1978) Pontiac fever: an epidemic of unknown etiology in a health department. I. Clinical and epidemiologic aspects. Am J Epidemiol 107, 149–160

    PubMed  CAS  Google Scholar 

  • Green EL (1981) Breeding systems. In The Mouse in Biomedical Research, HL Foster, JD Small, JG Fox, (eds) (New York: Academic Press), p 91

    Google Scholar 

  • Horwitz MA (1984) Phagocytosis of the Legionnaire’ disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell 36, 27–33

    Article  PubMed  CAS  Google Scholar 

  • Horwitz MA (1987) Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J Exp Med 166, 1310–1328

    Article  PubMed  CAS  Google Scholar 

  • Horwitz MA, Silverstein SC (1980) The Legionnaire’ disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes. J Clin Invest 66, 441–450

    Article  PubMed  CAS  Google Scholar 

  • Kishimoto RA, White JD, Shirey FG, McGann VG, Berendt RF, Larson EW, Hedlund KW (1981) In vitro response of guinea pig peritoneal macrophages to Legionella pneumophila. Infect Immun 31, 1209–1213

    PubMed  CAS  Google Scholar 

  • Lefebvre S, Burglen L, Reboullet S, Clermont O, Burlet P, Viollet L, Benichou B, Cruaud C, Millasseau P, Zeviani M, Paslier D, Frezal J, Cohen D, Weissenbach J, Munnich A, Melki J (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80, 155–165

    Article  PubMed  CAS  Google Scholar 

  • McDade JE, Shepard CC, Fraser DW, Tsai TR, Redus MA, Dowdle WR, The Laboratory Investigation Team (1977) Legionnaire’ disease. Isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297, 1197–1203

    PubMed  CAS  Google Scholar 

  • Müller A, Hacker J, Brand BC (1996) Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infect Immun 64, 4900–4906

    PubMed  Google Scholar 

  • Pizzuti A, Colosimo A, Ratti A, Capon F, Gennarelli M, Silani V, Ghezzi C, Cicero S, Calabrese G, Palka G, Scarlato G, Novelli G, Dallapiccola B (1995) Identification of multiple transcribed sequences from the spinal muscular atrophy region on human chromosome 5. Biochem Biophys Res Commun 206, 294–301

    Article  PubMed  CAS  Google Scholar 

  • Roy N, McLean MD, Besner-Johnston A, Lefebvre C, Salih M, Carpten JD, Burghes AHM, Yaraghi Z, Ikeda J-E, Korneluk RG, MacKenzie AE (1995a) Refined physical map of the spinal muscular atrophy gene (SMA) region at 5q13 based on YAC and cosmid contiguous arrays. Genomics 26, 451–460

    Article  PubMed  CAS  Google Scholar 

  • Roy N, Mahadevan MS, McLean MD, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X, Maysoon S, Aubry H, Tamai K, Guan X, Ioannou P, Crawford TO, Jong PJ, Surh L, Ikeda J-E, Korneluk RG, MacKenzie AE (1995b) The gene responsible for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80, 167–178

    Article  PubMed  CAS  Google Scholar 

  • Scharf JM, Damron D, Frisella A, Bruno S, Beggs AH, Kunkel LM, Dietrich WF (1996) The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains copies of Naip exon 5. Genomics 38, 405–417

    Article  PubMed  CAS  Google Scholar 

  • Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (1995) Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. Proc Natl Acad Sci USA 92, 3702–3706

    Article  PubMed  CAS  Google Scholar 

  • Swanson MS, Isberg RR (1995) Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun 65, 3609–3620

    Google Scholar 

  • van der Steege G, Draaijers TG, Grootscholten PM, Osinga J, Anzevino R, Velona I, Brahe C, Scheffer H, Ommen G-JB, Buys CHCM (1995) A provisional transcript map of the spinal muscular atrophy (SMA) critical region. Eur J Hum Genet 3, 87–95

    PubMed  Google Scholar 

  • Viollet L, Bertrandy S, Brunialti ALB, Lefebvre S, Burlet P, Clermont O, Cruaud C, Guenet J-L, Munnich A, Melki J (1997) cDNA isolation, expression and chromosomal localization of the mouse survival motor neuron gene (Smn). Genomics 40, 185–188

    Article  PubMed  CAS  Google Scholar 

  • Xu H-P, Yanak BL, Wigler MH, Gorin MB (1996) New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13. Mamm Genome 7, 16–19

    Article  PubMed  Google Scholar 

  • Yamamoto Y, Klein TW, Newton CA, Widen R, Friedman H (1988) Growth of Legionella pneumophila in thioglycollate-elicited peritoneal macrophages from A/J mice. Infect Immun 56, 370–375

    PubMed  CAS  Google Scholar 

  • Yamamoto Y, Klein TW, Friedman H (1994) Legionella and macrophages. (Review) Immunol Ser 60, 329–348

    PubMed  CAS  Google Scholar 

  • Yoshida S-I, Mizuguchi Y (1986) Multiplication of Legionella pneumophila Philadelphia-1 in cultured peritoneal macrophages and its correlation to susceptibility of animals. Can J Microbiol 32, 438–442

    Article  PubMed  CAS  Google Scholar 

  • Yoshida S-I, Goto Y, Mizuguchi Y, Nomoto K, Skamene E (1991) Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila replication in vitro. Infect Immun 59,428–432

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, McGill University, H3G-1Y6, Montreal, Canada

    Eduarto Diez & Philippe Gros

  2. Department of Genetics, Faculty of Veterinary Medicine, University of Liege, 4000, Liege, Belgium

    Marie-Claire Beckers, Eric Ernst & Philippe Gros

  3. Genetique Medicale, Hopital Sainte-Justine, H3T-1C5, Montreal, Quebec, Canada

    Christine J. DiDonato & Louise R. Simard

  4. Center for the Study of Host Resistance, Montreal General Hospital, H3G 1A4, Montreal, Canada

    Celine Morissette & Francine Gervais

  5. Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, 807, Kitakyushu, Japan

    Shin-Ichi Yoshida

Authors
  1. Eduarto Diez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie-Claire Beckers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eric Ernst
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christine J. DiDonato
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Louise R. Simard
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Celine Morissette
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Francine Gervais
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shin-Ichi Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Philippe Gros
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diez, E., Beckers, MC., Ernst, E. et al. Genetic and physical mapping of the mouse host resistance locus Lgn1 . Mammalian Genome 8, 682–685 (1997). https://doi.org/10.1007/s003359900536

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003359900536

Keywords

Search

Navigation