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Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae

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Abstract.

Bleomycin is a small glycopeptide antibiotic used in combination therapy for the treatment of a few types of human cancer. The antitumor effect of bleomycin is most likely caused by its ability to bind to DNA and induce the formation of toxic DNA lesions via a free radical reactive (Fe.bleomycin) complex. However, the chemotherapeutic potential of bleomycin is limited, as it causes pulmonary fibrosis and tumor resistance at high doses. The chemical structure and modes of action of bleomycin have been extensively studied and these provide a foundation towards improving the therapeutic value of the drug. This review provides a first account of the current state of knowledge of the cellular processes that can allow the yeast Saccharomyces cerevisiae to evade the lethal effects of bleomycin. This model organism is likely to provide rapid clues in our understanding of bleomycin resistance in tumor cells.

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Acknowledgements.

We thank Andrea Shatilla for critically reading the manuscript. This research was supported by the National Cancer Institute of Canada (NCIC) with funds from the Canadian Cancer Society. D.R. was supported by a career scientist award from the NCIC and presently by a senior fellowship from the Fonds de la Recherche en Sante du Quebec.

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  1. Maisonneuve-Rosemont Hospital, Guy-Bernier Research Center, 5415 Boulevard de l'Assomption, Montreal, Quebec, H1T 2M4, Canada

    Dindial Ramotar & Huijie Wang

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  1. Dindial Ramotar
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Correspondence to Dindial Ramotar.

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Ramotar, D., Wang, H. Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae . Curr Genet 43, 213–224 (2003). https://doi.org/10.1007/s00294-003-0396-1

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