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Dihydropyrimidine dehydrogenase deficiency in an Indian population

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Abstract

Background: Dihydropyrimidine dehydrogenase (DPD) deficiency is prevalent in 3–5% of the Caucasian population; however, the frequency of this pharmacogenetic syndrome in the Indian population and other racial and ethnic groups remains to be elucidated. Patients and methods: We describe an Indian patient who presented to clinic for the treatment of gastric adenocarcinoma with 5-flurouracil (5-FU) therapy who subsequently was diagnosed with DPD deficiency by using the peripheral blood mononuclear cell (PBMC) DPD radioassay. This observation prompted us to examine the data generated from healthy (cancer-free) Indian subjects who were enrolled in a large population study to determine the sensitivity and specificity of the uracil breath test (UraBT) in the detection of DPD deficiency. Thirteen Indian subjects performed the UraBT. UraBT results were confirmed by PBMC DPD radioassay. Results: The Indian cancer patient demonstrated reduced DPD activity (0.11 nmol/min/mg protein) and severe 5-FU toxicities commonly associated with DPD deficiency. Of the 13 Indian subjects [ten men and three women; mean age, 26 years (range: 21–31 years)] enrolled in the UraBT, 12 Indian subjects demonstrated UraBT breath profiles and PBMC DPD activity within the normal range; one Indian subject demonstrated a reduced breath profile and partial DPD deficiency. Conclusions: DPD deficiency is a pharmacogenetic syndrome which is also present in the Indian population. If undiagnosed, the DPD deficiency can lead to death. Future epidemiological studies would be helpful to determine the prevalence of DPD deficiency among racial and ethnic groups, allowing for the optimization of 5-FU chemotherapy.

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Acknowledgement

This work was supported in part by NIH grant CA 62164.

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Authors and Affiliations

  1. Yale University School of Medicine, New Haven, CT, USA

    Muhammad Wasif Saif

  2. University of Alabama at Birmingham, New Haven, CT, USA

    Lori Mattison, Tom Carollo, Hany Ezzeldin & Robert B. Diasio

  3. Section of Medical Oncology, Yale University School of Medicine, 333 Cedar Street; FMP 116, New Haven, CT, 06520, USA

    Muhammad Wasif Saif

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  1. Muhammad Wasif Saif
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  2. Lori Mattison
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  3. Tom Carollo
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  4. Hany Ezzeldin
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  5. Robert B. Diasio
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Correspondence to Muhammad Wasif Saif.

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Saif, M.W., Mattison, L., Carollo, T. et al. Dihydropyrimidine dehydrogenase deficiency in an Indian population. Cancer Chemother Pharmacol 58, 396–401 (2006). https://doi.org/10.1007/s00280-005-0174-5

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  • DOI: https://doi.org/10.1007/s00280-005-0174-5

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