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Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen

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Abstract.

In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8+ lymphocytes, reacted with recombinant BoCD26 expressed in COS-7 and CHO cells. We also showed that human CD8+ T cells stimulated by a superantigen expressed CD26 at high levels. These results demonstrate that ACT3 is identical to BoCD26 and suggest that CD26 upregulation on CD8+ T cells is a general phenomenon of superantigens and not limited to their effects on bovine cells.

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Authors and Affiliations

  1. Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844, USA, , , , ,

    Sang-Un Lee & Gregory A. Bohach

  2. Department of Microbiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Korea, , , , ,

    Yong-Ho Park

  3. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99163, USA, , , , ,

    William C. Davis & Mary Hamilton

  4. International Livestock Research Institute, Nairobi, Kenya, , , , ,

    Jan Naessens

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  1. Sang-Un Lee
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  2. Yong-Ho Park
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  3. William C. Davis
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  4. Mary Hamilton
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  5. Jan Naessens
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  6. Gregory A. Bohach
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Lee, SU., Park, YH., Davis, W.C. et al. Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen. Immunogenetics 54, 216–220 (2002). https://doi.org/10.1007/s00251-002-0456-6

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  • DOI: https://doi.org/10.1007/s00251-002-0456-6

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