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Role of Collecting Duct Urea Transporters in the Kidney – Insights from Mouse Models

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Abstract

Urea movement across plasma membranes is modulated by specialized urea transporter proteins. These proteins are proposed to play key roles in the urinary concentrating mechanism and fluid homeostasis. To date, two urea-transporter genes have been cloned; UT-A (Slc14a2), encoding at least five proteins and UT-B (Slc14a1) encoding a single protein isoform. Recently we engineered mice that lack the inner medullary collecting duct (IMCD) urea transporters, UT-A1 and UT-A3 (UT-A1/3 −/− mice). This article includes 1) a historical review of the role of renal urea transporters in renal function; 2) a review of our studies utilizing the UT-A1/3 −/− mice; 3) description of an additional line of transgenic mice in which beta-galactosidase expression is driven by the alpha-promoter of the UT-A gene, which is allowing better physiological definition of control mechanisms for UT-A expression; and 4) a discussion of the implications of the studies in transgenic mice for the teaching of kidney physiology.

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Acknowledgment

The work described in this paper was supported in part by the Intramural Budget of the National Heart, Lung and Blood Institute (Project ZO1-HL-01282-KE) to M. A. Knepper. The Water and Salt Research Center at the University of Aarhus is established and supported by the Danish National Research Foundation (Danmarks Grundforskningsfond). R. A. Fenton is supported by the Carlsberg Foundation (Carlsbergfondet), the Nordic Council (the Nordic Centre of Excellence Programme in Molecular Medicine) and the Danish National Research Foundation. C. P. Smith is supported by The Royal Society and the BBSRC.

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  1. The Water and Salt Research Center, Institute of Anatomy, Building 1233, University of Aarhus, DK-8000, Aarhus, Denmark

    R. A. Fenton

  2. Faculty of Life Sciences, University of Manchester, Oxford Rd, Manchester, UK

    C.P. Smith

  3. Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, Bethesda, MD, 20892, USA

    M.A. Knepper

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  1. R. A. Fenton
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Fenton, R.A., Smith, C. & Knepper, M. Role of Collecting Duct Urea Transporters in the Kidney – Insights from Mouse Models. J Membrane Biol 212, 119–131 (2006). https://doi.org/10.1007/s00232-006-0871-y

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