Abstract
Stroke induces bilateral neurological impairment and muscle weakness yielding neurologically more (MA; paretic) and less affected (LA; non-paretic) sides. “Cross-education” refers to training one side of the body to increase strength in the same muscles on the untrained side. Past work showed dorsiflexion training of the LA side produced bilateral strength increases after stroke. The current study explored the presence and extent of cross-education after arm strength training in chronic stroke. Twenty-four chronic stroke participants completed 5 weeks of maximal wrist extension training using their LA arm. Maximal voluntary contraction force, arm motor impairment and functional performance were measured before and after training. Both spinal cord plasticity (n = 12: reciprocal inhibition and cutaneous reflexes, University of Victoria) and cortical plasticity (n = 12: cortical silent period, short-interval intracortical inhibition, intracortical facilitation and transcallosal inhibition, University of British Columbia) were assessed. Five weeks after training, 20 participants completed a follow-up maximal wrist extension retention test. LA wrist extension force increased 42% and MA by 35%. Strength gains were maintained in the follow-up test. Clinically meaningful increases in Fugl-Meyer scores were noted in four participants. Muscle activation was correlated with cutaneous reflex amplitudes after training in the MA arm. LA cortical silent period and transcallosal inhibition from both hemispheres significantly decreased after training. This study shows that high-intensity training with the neurologically less affected “non-paretic” arm can improve strength bilaterally and alter both spinal and cortical plasticity. The extent to which this plasticity can be enhanced or functionally exploited remains to be examined.
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Acknowledgements
Dr. E.Paul Zehr’s research was supported by funding from the Heart and Stroke Foundation (British Columbia and Yukon). Yao Sun was supported by a Focus on Stroke doctoral award from the Heart and Stroke Foundation of Canada. Data collection at UBC was funded by an operating grant from the Canadian Institutes of Health Research operating Grant (MOP-106651) awarded to Dr. Lara Boyd. The authors also wish to acknowledge Matt Jensen’s contribution in designing, making and instrumenting the training devices.
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Sun, Y., Ledwell, N.M.H., Boyd, L.A. et al. Unilateral wrist extension training after stroke improves strength and neural plasticity in both arms. Exp Brain Res 236, 2009–2021 (2018). https://doi.org/10.1007/s00221-018-5275-6
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DOI: https://doi.org/10.1007/s00221-018-5275-6