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Comparing movement patterns associated with Huntington’s chorea and Parkinson’s dyskinesia

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Abstract

Involuntary movements such as levodopa-induced dyskinesia in Parkinson’s disease (PD) and chorea in Huntington’s disease (HD) are the consequence of two distinct basal ganglia dysfunctions. Yet, their clinical manifestations seem to resemble each other. We seek to determine how to detect PD dyskinesia and HD chorea during quiet stance using healthy control subjects’ postural sway as a base measure and identify means to distinguish mathematically HD chorea from PD dyskinesia. Movements were recorded using a magnetic tracker system with fifteen sensors placed strategically to capture whole-body displacement. Choreic and dyskinetic patients as well as healthy controls were asked to stand with arms stretched horizontally in front of them for 60 s. We examined amplitude, frequency dispersion, proportional energy, sample entropy, kurtosis, skewness, amplitude fluctuation, maximum coherency between 44 pairs of body segments. The choreic and dyskinetic movements revealed similar patterns of sample entropy, amplitude fluctuation, and coherencies between body segments. However, skewness and kurtosis for velocity of movements were found to be higher in HD chorea than in PD dyskinesia, reflecting rapid movements in HD patients. There was also a tendency for the frequency composition of PD dyskinesia to be more concentrated in the 1.0–1.5 Hz range. Our results show that despite their similarities in apparent randomness and lack of coordination, dyskinesia associated with treatment of PD and chorea in HD each have their own distinctive characteristics which may be related to their specific pathophysiology.

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Acknowledgments

The authors would like to thank the subjects who graciously participated in the study. This study was funded by Parkinson Society Canada, the Natural Sciences and Engineering Research Council of Canada, the Canadian Foundation for Innovation and the Canadian Institutes of Health Research.

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Authors and Affiliations

  1. Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada

    Rena K. Mann, Roderick Edwards & Julie Zhou

  2. McMaster Integrative Neuroscience Discovery and Study, McMaster University, Hamilton, ON, Canada

    Alison Fenney

  3. Department of Clinical Neurological Sciences, NPF Centre of Excellence in Parkinson Disease, University of Western Ontario, London, ON, Canada

    Mandar Jog

  4. Département de Kinanthropologie, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montreal, QC, Canada

    Christian Duval

Authors
  1. Rena K. Mann
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  2. Roderick Edwards
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  3. Julie Zhou
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  4. Alison Fenney
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  5. Mandar Jog
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  6. Christian Duval
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Correspondence to Christian Duval.

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Mann, R.K., Edwards, R., Zhou, J. et al. Comparing movement patterns associated with Huntington’s chorea and Parkinson’s dyskinesia. Exp Brain Res 218, 639–654 (2012). https://doi.org/10.1007/s00221-012-3057-0

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  • DOI: https://doi.org/10.1007/s00221-012-3057-0

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