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Optical imaging of digit topography in individual awake and anesthetized squirrel monkeys

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Abstract

Topographic maps and columnar structures are fundamental to cortical sensory information processing. Most of the knowledge about detailed topographic maps and columnar structure comes mainly from experiments conducted on anesthetized animals. Towards the goal of evaluating whether topographic maps change with respect to behavioral demands, we used intrinsic signal optical imaging in alert monkeys to examine the spatial specificity of cortical topographic representation. Specifically, the somatotopies of neighboring distal finger pad representation in areas 3b and 1 were examined in the same awake and anesthetized squirrel monkey. In comparison to the anesthetized animal, we found larger cortical activation sizes in the alert animal in area 3b, where activation widths were found to overlap with even non-adjacent digits. This may suggest that in the alert animal, there is less inhibition across the somatotopic map within area 3b.

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Acknowledgments

We thank Barbara Heider and Francine Healy for assistance on initial experiments. Supported by NIH NS044375 (AWR) and DE16606 (LMC).

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Authors and Affiliations

  1. Department of Radiology and Radiological Science, Institute of Imaging Science, Vanderbilt University, AA 1105 MCN, 1161 21st Avenue, Nashville, TN, 37203, USA

    Li Min Chen

  2. Department of Psychology, Vanderbilt University, Nashville, TN, 37203, USA

    Robert Mark Friedman & Anna Wang Roe

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  1. Li Min Chen
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Correspondence to Li Min Chen.

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Chen, L.M., Friedman, R.M. & Roe, A.W. Optical imaging of digit topography in individual awake and anesthetized squirrel monkeys. Exp Brain Res 196, 393–401 (2009). https://doi.org/10.1007/s00221-009-1861-y

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