Abstract
The recent synthetic development of a variety of nanoparticles has led to their widespread application in diagnostics and therapeutics. In particular, the controlled size and shape of nanoparticles precisely determine their unique chemical and physical properties, which is highly attractive for accurate analysis of given systems. In addition to efforts toward controlling the synthesis and properties of nanoparticles, the surface functionalization of nanoparticles with biomolecules has been intensively investigated since the mid-1990s. The complicated yet programmable properties of biomolecules have proved to substantially enhance and enrich the novel functions of nanoparticles to achieve “smart” nanoparticle materials. In this review, the advances in chemical functionalization of four types of representative nanoparticle with DNA and protein molecules in the past five years are critically reviewed, and their future trends are predicted.
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Abbreviations
- A:
-
Adenine
- AgNP:
-
Gold nanoparticle
- AuNP:
-
Silver nanoparticle
- BRET:
-
Bioluminescence resonance energy transfer
- CNT:
-
Carbon nanotube
- Cu-CAA:
-
Cu+-catalyzed cycloaddition of alkyne and azide groups
- dATP:
-
Deoxyadenosine triphosphate
- DMBA:
-
4-(Dimethylamino)butyric acid
- DTT:
-
Dithiotheritol
- EDC:
-
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
- ELISA:
-
Enzyme-linked immunosorbent assay
- FRET:
-
Förster resonance energy transfer
- GPMS:
-
γ-Glycidoxypropyltrimethoxysilane
- GSH:
-
Glutathione
- HEK 293 cell:
-
Human embryonic kidney 293 cell
- His6:
-
Hexa-histidine
- HRP:
-
Horseradish peroxidase
- Mal:
-
Maleimide group
- MPTMS:
-
(3-Mercaptopropyl)trimethoxysilane
- NHS:
-
N-Hydroxysuccinimide
- NMDAR:
-
N-Methyl-D-aspartate receptor
- NP:
-
Nanoparticle
- PCR:
-
Polymerase chain reaction
- PEG:
-
Poly(ethylene glycol)
- polyA:
-
Polyadenine
- QD:
-
Quantum dot
- Ru(bpy)3 2+ :
-
Tris(2,2-bipyridyl)ruthenium(II)
- SAM:
-
Self-assembled monolayer
- SERS:
-
Surface-enhanced Raman spectroscopy
- SiO2NP:
-
Silica nanoparticle
- STZ:
-
Sulfathiazole
- Sulfo-SMCC:
-
Sulfosuccinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate
- T:
-
Thymine
- TCEP:
-
Tris(2-carboxyethyl)phosphine
- TEOS:
-
Tetraethylorthosilicate
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With respect to QDs, the number of publications using streptavidin/biotin coupling is approximately 10 times as large as those using dithiol or hexahistidine anchoring groups, and approximately 25 times as large as the total number of publications using HaloTag, SpyCatcher-SpyTag coupling, and inteins. The publications since 2009 were searched in Webofscience as of July 2015
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Acknowledgment
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant No. NRF-2012R1A1A2A10042814) and Brain Korea 21 Plus Project in 2015.
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The authors declare that they have no conflict of interest.
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Oh, JH., Park, D.H., Joo, J.H. et al. Recent advances in chemical functionalization of nanoparticles with biomolecules for analytical applications. Anal Bioanal Chem 407, 8627–8645 (2015). https://doi.org/10.1007/s00216-015-8981-y
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DOI: https://doi.org/10.1007/s00216-015-8981-y