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Porous monoliths: sorbents for miniaturized extraction in biological analysis

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Abstract

In this review the focus is on application of porous monoliths to miniaturized extraction of biological analysis, with emphasis on porous monolithic materials and different miniaturized extraction formats. The general approaches used to synthesize organic polymer and silica monolithic materials are highlighted, and their properties and applicability are described and compared. Several extraction formats, including in-tube microextraction, chip-based microextraction, tip-based microextraction, among others, are reviewed in depth.

A visual model of the miniaturized extraction based on porous monoliths

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Acknowledgements

This work was partly supported by grants from the National Science Fund for Distinguished Young Scholars (no. 20625516), the National Key Technologies R&D Program (2006BAF07B03), and the Science Fund for Creative Research Groups (no. 20921062), NSFC.

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Authors and Affiliations

  1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China

    Li Xu

  2. Department of Chemistry, Wuhan University, Wuhan, 430072, China

    Zhi-Guo Shi & Yu-Qi Feng

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  1. Li Xu
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  2. Zhi-Guo Shi
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Correspondence to Yu-Qi Feng.

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Published in the special issue Analytical and Bioanalytical Science in China with Guest Editors Lihua Zhang, Qiankun Zhuang, and Yukui Zhang.

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Xu, L., Shi, ZG. & Feng, YQ. Porous monoliths: sorbents for miniaturized extraction in biological analysis. Anal Bioanal Chem 399, 3345–3357 (2011). https://doi.org/10.1007/s00216-010-4190-x

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