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New methods for nanotoxicology: synchrotron radiation-based techniques

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Abstract

Nanotoxicology, a new branch of bionanoscience, deals with the study and application of the toxic or biological effects of nanomaterials or nanostructures, and aims to fill gaps in our knowledge of interactions between nano- and biosystems. However, progress in this new discipline largely relies on developing methodology to characterize nanomaterials in biological samples, quantify nanoparticles in living systems, and study their uptake, translocation, biodistribution, location and chemical status in vitro and in vivo, etc. In this review article, we focus on the main features of synchrotron radiation-based methods and their application to the study of the toxicological activities of nanomaterials. Synchrotron radiation-based analytical techniques are shown to provide a potent means for characterizing the toxic or biological behaviors of nanoparticles in biological systems.

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Acknowledgements

The authors are grateful to the Foundations of the MOST 973 program (2006CB705605, 2009CB930204), the CAS Knowledge Innovation Program (KJCX3.SYW.N3), and the National Natural Science Foundation of China (10975148, 10905064 and 20805048), and 973 program 2010CB933904.

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Authors and Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China

    Bing Wang, Weiyue Feng, Meng Wang, Zhifang Chai & Yuliang Zhao

  2. The College of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of Sciences, Beijing, 100049, China

    Zhe Wang, Zhongbo Hu & Yuliang Zhao

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  1. Bing Wang
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  2. Zhe Wang
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  3. Weiyue Feng
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  4. Meng Wang
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  6. Zhifang Chai
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  7. Yuliang Zhao
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Correspondence to Weiyue Feng or Yuliang Zhao.

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Wang, B., Wang, Z., Feng, W. et al. New methods for nanotoxicology: synchrotron radiation-based techniques. Anal Bioanal Chem 398, 667–676 (2010). https://doi.org/10.1007/s00216-010-3752-2

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