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Field-based ion generation from microscale emitters on natural and artificial objects for atmospheric pressure mass spectrometry

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Abstract

Field-based ion generation is described for ambient mass spectrometry. The technique allows the analysis of endogenously expressed chemicals and exogenously applied compounds directly from the cuticle of live insects in real time. Cuticular hairs serve as electric field-enhancing structures and play a key role in ion generation. Artificial emitters such as graphite whiskers or sharp metal tips replicate this effect.

Fruit fly in front of the ion trap entrance capillary (see file Online_abstract_figure.jpg).

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Abbreviations

AP:

Atmospheric pressure

APCI:

Atmospheric pressure chemical ionization

DART:

Direct analysis in real time

DESI:

Desorption electrospray ionization

ESI:

Electrospray ionization

FBIG:

Field-based ion generation

FD/FI:

Field desorption/field ionization

HC:

Hydrocarbon

HC1:

Z-11-Hexadecenyl acetate

HC2:

Z-11-Hexadecen-1-ol

HC3:

Z-11-Hexadecenal

IR:

Infrared

IT:

Ion trap

MALDI:

Matrix-assisted laser desorption/ionization

MS:

Mass spectrometry

PESI:

Probe electrospray ionization

Q-TOF:

Quadrupole time-of-flight

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Acknowledgments

K.D. acknowledges a grant from the German Research Foundation (DFG DR416/5-1). J.Y. was supported by a Human Frontier Science Program short-term fellowship and partly by grants to Prof. E.A. Kravitz from the National Institute of General Medical Sciences (GM074675 and GM067645) and National Science Foundation (IDS-075165). Scanning electron microscopy experiments were performed in the group of Prof. Dr. R. Reichelt (Institut für Medizinische Physik und Biophysik, Westfälische Wilhelms-Universität Münster) by Mrs. U. Keller and are highly appreciated. The authors also thank K. Rix for technical assistance.

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Authors and Affiliations

  1. Integrierte Funktionelle Genomik, Interdisziplinäres Zentrum für Klinische Forschung, Westfälische Wilhelms-Universität, Münster, Germany

    Alexander Pirkl & Simone König

  2. Institut für Medizinische Physik und Biophysik, Westfälische Wilhelms-Universität, Münster, Germany

    Klaus Dreisewerd

  3. Department of Neurobiology, Harvard Medical School, Boston, MA, USA

    Joanne Y. Yew

Authors
  1. Alexander Pirkl
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  2. Klaus Dreisewerd
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  3. Joanne Y. Yew
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  4. Simone König
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Correspondence to Simone König.

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Pirkl, A., Dreisewerd, K., Yew, J.Y. et al. Field-based ion generation from microscale emitters on natural and artificial objects for atmospheric pressure mass spectrometry. Anal Bioanal Chem 397, 3311–3316 (2010). https://doi.org/10.1007/s00216-009-3184-z

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  • DOI: https://doi.org/10.1007/s00216-009-3184-z

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