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Effect of Cu(II) on the electrochemically initiated reaction of thiols with N,N-diethyl-p-phenylenediamine: methodology for the indirect voltammetric determination of Cu(II)

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Abstract

The effect of Cu(II) on the determination of homocysteine via its electrochemically initiated reaction with N,N-diethyl-p-phenylenediamine is examined. The presence of copper inhibited the detection process for homocysteine owing to a complexation reaction occurring. This provided an indirect route for the sensitive and selective determination of Cu(II), which produced a linear response over the range from 2.5 to 500 μM and a limit of detection of 2.5 μM. The detection pathway was examined in the presence of metallic and inorganic ions, with negligible interference observed.

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Acknowledgements

NSL thanks the EPSRC and Schlumberger Cambridge Research for financial support of his project. ON thanks the Analytical Division of The Royal Society of Chemistry for a studentship. CEB thanks the EPSRC for funding via a project studentship (Grant GR/R14392/01).

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Authors and Affiliations

  1. Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK

    Jessica A. Kershaw, Olga Nekrassova, Craig E. Banks, Nathan S. Lawrence & Richard G. Compton

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  1. Jessica A. Kershaw
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  2. Olga Nekrassova
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  3. Craig E. Banks
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  4. Nathan S. Lawrence
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  5. Richard G. Compton
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Correspondence to Richard G. Compton.

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Kershaw, J.A., Nekrassova, O., Banks, C.E. et al. Effect of Cu(II) on the electrochemically initiated reaction of thiols with N,N-diethyl-p-phenylenediamine: methodology for the indirect voltammetric determination of Cu(II). Anal Bioanal Chem 379, 707–713 (2004). https://doi.org/10.1007/s00216-004-2644-8

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  • DOI: https://doi.org/10.1007/s00216-004-2644-8

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