Abstract
Perinatal depression is the most common complication of pregnancy and affects the mother, fetus, and infant. Recent preclinical studies and a limited number of clinical studies have suggested an influence of the gut microbiome on the onset and course of mental health disorders. In this review, we examine the current state of knowledge regarding genetics, epigenetics, heritability, and neuro-immuno-endocrine systems biology in perinatal mood disorders, with a particular focus on the interaction between these factors and the gut microbiome, which is mediated via the gut-brain axis. We also provide an overview of experimental and analytical methods that are currently available to researchers interested in elucidating the influence of the gut microbiome on mental health disorders during pregnancy and postpartum.
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18 March 2022
A Correction to this paper has been published: https://doi.org/10.1007/s00213-022-06102-y
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BPB is funded by the Arnold O Beckman Postdoctoral Award.
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BPB, PMM, and JAG conceived the manuscript; SD and MSG designed the figures. All the authors wrote, edited, and revised the manuscript.
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The original version of this article was revised: The authors regret that Figure 2, a drawing of the microbiome-gut-brain axis during pregnancy, included a misrepresentation of Black women.
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Peñalver Bernabé, B., Maki, P.M., Dowty, S.M. et al. Precision medicine in perinatal depression in light of the human microbiome. Psychopharmacology 237, 915–941 (2020). https://doi.org/10.1007/s00213-019-05436-4
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DOI: https://doi.org/10.1007/s00213-019-05436-4