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Social setting, social rank and HPA axis response in cynomolgus monkeys

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Abstract

Rationale

Hypothalamic-pituitary-adrenal (HPA) axis activity under different social settings in non-human primates is understudied.

Objective

The aim of this study is to evaluate the response of pituitary-adrenal hormones (adrenocorticotropic hormone (ACTH) and cortisol) to pharmacological challenges of the HPA axis in male cynomolgus macaques under different social settings.

Methods

Male cynomolgus macaques (Macaca fascicularis, n = 11) were individually (A) and socially housed (B) in alternation, over consecutive months, in an ABA design. During each experimental phase, plasma ACTH and cortisol were measured in response to low- and mild-intensity psychological stressors and following administration of saline, naloxone, ovine-corticotropin-releasing factor (oCRF), and dexamethasone.

Results

These data demonstrate that cortisol measured under low stress conditions is sensitive to social rank (dominance hierarchy) and distinguishes dominant from non-dominant animals during both individual and social settings. Administration of naloxone resulted in elevated circulating ACTH and cortisol, while oCRF only increased circulating cortisol. During social housing, the cortisol response to naloxone and oCRF was increased, whereas dexamethasone suppression of ACTH and cortisol remained consistent across all social settings.

Conclusions

Circulating ACTH and cortisol are differentially sensitive to changes in social settings in non-human primates. Cortisol response increased during social housing and could be stimulated by both naloxone and oCRF, whereas ACTH response was generally not influenced by social setting or oCRF but was increased by naloxone. These data show differential adrenal and pituitary response to changes in social settings and a small, but consistent, effect of social dominance.

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Acknowledgements

This work and preparation of the manuscript was supported by AA103510, the supplement to AA013510 and OD11092. The authors wish to thank Dr. Christa Helms who provided initial analysis of the data.

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Authors and Affiliations

  1. Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97202, USA

    Vanessa A. Jimenez, Daicia C. Allen, Megan N. McClintick & Kathleen A. Grant

  2. Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR, 97006, USA

    Kathleen A. Grant

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  1. Vanessa A. Jimenez
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  2. Daicia C. Allen
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  3. Megan N. McClintick
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  4. Kathleen A. Grant
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Correspondence to Kathleen A. Grant.

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Jimenez, V.A., Allen, D.C., McClintick, M.N. et al. Social setting, social rank and HPA axis response in cynomolgus monkeys. Psychopharmacology 234, 1881–1889 (2017). https://doi.org/10.1007/s00213-017-4596-7

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  • DOI: https://doi.org/10.1007/s00213-017-4596-7

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