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An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

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Abstract

We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1–5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.

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Abbreviations

IGT :

Impairment in glucose tolerance

NPL :

Nonparametric linkage

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Acknowledgements

This work was supported by grants from the National Science Foundation of China (no. 30170441), the National High Technology Research and Development Program (no. 2001AA221161, no. 2002BA711A05, no. 2002BA711A10-02), the National Program for Key Basic Research Projects (no. G1998051016), and Natural Science Foundation of Beijing (no. 7002026)

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 100005, Beijing, China

    J. Y. Zhao, J. Zuo, G. D. Wu, M. L. Zhang & F. D. Fang

  2. Human Genetics Center, University of Texas-Houston, Houston, TX, 77225, USA

    J. Y. Zhao, M. M. Xiong, L. Jin & E. Boerwinkle

  3. Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China

    W. Huang & Z. Chen

  4. Department of Endocrinology, Peking Union Medical College Hospital, 100730, Beijing, China

    H. Wang, Y. X. Li, Q. Sun & Q. Y. Liu

  5. Chinese National Human Genome Center at Beijing, 100005, Beijing, China

    B. Q. Qiang

  6. Shanghai Institute of Endocrinology, 200025, Shanghai, China

    J. L. Chen & W. Ding

  7. Ruijin Hospital, Shanghai Second Medical University, 200025, Shanghai, China

    W. T. Yuan

  8. Morgan-Tan International Center for Biological Sciences, Fudan University, 200433, Shanghai, China

    H. Y. Xu & L. Jin

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  1. J. Y. Zhao
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  2. M. M. Xiong
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Correspondence to F. D. Fang.

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Zhao, J.Y., Xiong, M.M., Huang, W. et al. An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. J Mol Med 83, 209–215 (2005). https://doi.org/10.1007/s00109-004-0587-3

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