Abstract
The antimicrobial activity of five novel SQ109 derivatives including SQ109 against bacteria, yeast and filamentous fungi is reported herein. Using broth microdilution techniques, compounds 2 and 3 were found to be active against most tested fungi and bacteria, with minimum inhibitory concentrations (MICs) ranging from 0.98 to 31 μg ml−1, except for Klebsiella pneumonia where the MIC was 250 μg ml−1. SQ109 and derivative 4 did not show any significant activity against most of the organisms used. However, their reduced derivatives 1 and 5 showed promising activity with MICs between 0.49 and 62.5 μg ml−1 against most of the microorganisms used.
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Acknowledgments
We thank the National Research Foundation, Gun 2046819, Aspen Pharmacare and the University of KwaZulu-Natal for financial support. We also thank Miss Siveshni Govender, School of Biological and Conservational Sciences for providing technical assistance during the BMM biological testing of these compounds.
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Onajole, O.K., Belewa, X.V., Coovadia, Y. et al. SQ109 analogues as potential antimicrobial candidates. Med Chem Res 20, 1394–1401 (2011). https://doi.org/10.1007/s00044-010-9490-3
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DOI: https://doi.org/10.1007/s00044-010-9490-3