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Cellular factors modulating the mechanism of tau protein aggregation

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Abstract

Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer’s disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer’s disease, a number of neurodegenerative diseases, called tauopathies, are characterized by the accumulation of aggregated tau in a variety of brain regions. While tau normally plays an important role in stabilizing the microtubule network of the cytoskeleton, its dissociation from microtubules and eventual aggregation into pathological deposits is an area of intense focus for therapeutic development. Here we discuss the known cellular factors that affect tau aggregation, from post-translational modifications to molecular chaperones.

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Acknowledgments

This work was supported by NS073899 to C.A.D.

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  1. Department of Molecular Medicine, College of Medicine, Byrd Alzheimer’s Institute, University of South Florida, Tampa, FL, 33613, USA

    Sarah N. Fontaine, Jonathan J. Sabbagh, Jeremy Baker, Carlos R. Martinez-Licha, April Darling & Chad A. Dickey

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  1. Sarah N. Fontaine
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  2. Jonathan J. Sabbagh
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Correspondence to Chad A. Dickey.

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Fontaine, S.N., Sabbagh, J.J., Baker, J. et al. Cellular factors modulating the mechanism of tau protein aggregation. Cell. Mol. Life Sci. 72, 1863–1879 (2015). https://doi.org/10.1007/s00018-015-1839-9

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  • DOI: https://doi.org/10.1007/s00018-015-1839-9

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