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Histone chaperone CAF-1: essential roles in multi-cellular organism development

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Abstract

More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (NSFC) [Nos. 31271573, 31228015, 31201007, 81470846] and the 973 Program [2012CB825504]. We are grateful to Gabriel Calvin and Jen Kennedy for critical reading of the manuscript. We thank the anonymous reviewers for constructive suggestions.

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Authors and Affiliations

  1. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, Beijing, 100101, China

    Zhongsheng Yu, Jiyong Liu & Renjie Jiao

  2. University of Chinese Academy of Sciences, Beijing, 100080, China

    Zhongsheng Yu & Renjie Jiao

  3. Guangzhou Hoffmann Institute of Immunology, School of Basic Sciences, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510182, China

    Jiyong Liu & Renjie Jiao

  4. Department of Biological Science, Florida State University, Tallahassee, FL, 32304-4295, USA

    Wu-Min Deng

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  1. Zhongsheng Yu
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  2. Jiyong Liu
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  3. Wu-Min Deng
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  4. Renjie Jiao
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Correspondence to Renjie Jiao.

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Z. Yu and J. Liu contributed equally to this work.

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Yu, Z., Liu, J., Deng, WM. et al. Histone chaperone CAF-1: essential roles in multi-cellular organism development. Cell. Mol. Life Sci. 72, 327–337 (2015). https://doi.org/10.1007/s00018-014-1748-3

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  • DOI: https://doi.org/10.1007/s00018-014-1748-3

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