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Application of Aptamers for Targeted Therapeutics

  • Review
  • Published:
Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Aptamers are short, single-stranded oligonucleotides that are isolated through a process termed systematic evolution of ligands by exponential enrichment. With the advent of cell-based selection technology, aptamers can be selected to bind protein targets that are expressed on the cell surface. These aptamers demonstrate excellent specificity and high affinity toward their target proteins and are often internalized upon binding to their targets. This has opened up the possibility of using aptamers for cell-specific targeted drug delivery. In this review, we will discuss cell-surface protein targets, the aptamers that bind them, and their applications for targeted therapeutics.

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  1. Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC, 27710, USA

    Partha Ray, Kristi D. Viles, Erin E. Soule & Rebecca Smock Woodruff

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  1. Partha Ray
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  2. Kristi D. Viles
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  3. Erin E. Soule
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  4. Rebecca Smock Woodruff
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Correspondence to Partha Ray.

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Ray, P., Viles, K.D., Soule, E.E. et al. Application of Aptamers for Targeted Therapeutics. Arch. Immunol. Ther. Exp. 61, 255–271 (2013). https://doi.org/10.1007/s00005-013-0227-0

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