Abstract.
The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic gradients. The reasons why some labs have recorded such gradients, whilst other workers see equilibration of Ca2+ cyt and Ca2+ nuc using the same cells and techniques, is unexplained. Furthermore, how such gradients could arise across the NE that possesses many highly-conductive NPCs is a mystery. Although nuclei may have the capacity to be autonomous signalling entities, with functional Ca2+ release channels and an inositide cycle, the balance of evidence suggests that Ca2+ release on the inner NE does not occur during physiological stimulation. Our work suggests that elementary Ca2+ release events originating in the cytoplasm can give rise to Ca2+ nuc signals without causing elevation of the bulk cytoplasm. Clearly, the many Ca2+ signalling mechanisms that may impinge on Ca2+ nuc will remain a topic of controversy and debate for some time.
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Bootman*, M., Thomas, D., Tovey, S. et al. Nuclear calcium signalling . CMLS, Cell. Mol. Life Sci. 57, 371–378 (2000). https://doi.org/10.1007/PL00000699
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DOI: https://doi.org/10.1007/PL00000699