Abstract:
The peripheral nuclear lamina is located near the nuclear inner membrane and consists of lamin filaments and integral membrane proteins, including the lamin B receptor and various isoforms of lamina-associated polypeptides (LAP) 1 and 2. Several nuclear membrane proteins also interact with chromatin proteins BAF and Hp1. Lamins in the nuclear interior associate with at least one soluble (non-membrane-bound) LAP2 isoform named LAP2α. The internal lamins, together with Tpr-based filaments that connect to nuclear pore complexes, are proposed to be major structural elements of the internal nuclear matrix. We describe the structural links between the peripheral lamina and the internal nuclear matrix that are thought to be mediated by LAP2 family members, filament protein Tpr and nucleoporin Nup153. These findings are discussed in relation to human diseases that arise from mutations in nuclear lamina proteins.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Rights and permissions
About this article
Cite this article
Vlcek, S., Dechat, T. & Foisner, R. Nuclear envelope and nuclear matrix: interactions and dynamics. CMLS, Cell. Mol. Life Sci. 58, 1758–1765 (2001). https://doi.org/10.1007/PL00000815
Issue Date:
DOI: https://doi.org/10.1007/PL00000815