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Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice

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Abstract.

Originally described as the signal-transducing pathway of interferons, the JAK-STAT pathway soon turned out to participate in the signalling of numerous other immune and even non-immune mediators. Several murine knockout models have been described that underline the biological significance of this signalling system. Some human diseases (mainly neoplastic) are also known where malfunctioning of the JAK-STAT pathway is considered to participate in the pathogenesis. In this brief review article we will try to make a synopsis of its biological and clinical significance.

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Authors and Affiliations

  1. 2nd Department of Medicine, Semmelweis University, Faculty of Medicine, H-1088 Budapest, Szentkirályi utca 46, Hungary, , , , , , HU

    P. Igaz

  2. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Medical School, H-1089 Budapest, Nagyvárad tér 4, Hungary, Fax: ++36 1 303 69 68, e-mail: FALAND@dgci.sote.hu, , , , , , HU

    S. Tóth & A. Falus

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  1. P. Igaz
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  2. S. Tóth
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  3. A. Falus
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Received 30 November 2000; returned for revision 15 January 2001; returned for final revision 29 March 2001; accepted by E. Neugebauer 8 May 2001

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Igaz, P., Tóth, S. & Falus, A. Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice. Inflamm. res. 50, 435–441 (2001). https://doi.org/10.1007/PL00000267

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  • DOI: https://doi.org/10.1007/PL00000267

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