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Biological activities of amyloid precursor protein

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Abstract

Amyloid precursor protein (APP), a transmembrane glycoprotein, is the source of amyloidogenic β-amyloid peptide (βAP), the major constituent of the peptides deposited in senile plaques. Normallycleaved forms of APP exert potent neuroprotective action. Accumulating data suggest that an altered expression and/or post-translational processing of APP is responsible for the neuropathological changes observed in Alzheimer’s disease and related disorders. This review discusses the metabolism and secretion of APP, the biological activities of the various APP forms, and the physiological, pathophysiological and experimental circumstances that affect the APP metabolism.

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  1. Department of Zoology and Cell Biology, University of Szeged, H-6722, Szeged, Egyetem u. 2, P.O. Box 659, Hungary

    K. Gulya

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Dedicated to Professor Peter Kasa on the occasion of the 25th anniversary of his appointment as Head of the Central Research Laboratory and the Alzheimer’s Disease Research Centre.

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Gulya, K. Biological activities of amyloid precursor protein. BIOLOGIA FUTURA 49, 7–27 (1998). https://doi.org/10.1007/BF03542974

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