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Desorption of Water from CD/DRUG Inclusion Complexes

Thermal behaviour — crystal structure correlation

  • Special Publication of Cyclodextrins and Their Inclusion Complexes
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Abstract

Thermogravimetric and differential scanning calorimetric traces were recorded for several crystalline hydrated cyclodextrin complexes containing drug substances (salts of diclofenac, meclofenamate sodium, (L)-menthol) as guests. It was possible to reconcile observed thermal events for complex dehydration with three dimensional hydration patterns deduced from available X-ray crystal structures of the complexes. For complexes containing drug salts, strong retention of water molecules is attributed to their coordination to metal ions.

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References

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Authors and Affiliations

  1. Department of Chemistry, University of Cape Town, Rondebosch, 7700, South Africa

    M. R. Caira, V. J. Griffith & L. R. Nassimbeni

Authors
  1. M. R. Caira
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  2. V. J. Griffith
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  3. L. R. Nassimbeni
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Caira, M.R., Griffith, V.J. & Nassimbeni, L.R. Desorption of Water from CD/DRUG Inclusion Complexes. Journal of Thermal Analysis 51, 981–991 (1998). https://doi.org/10.1007/BF03341478

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  • DOI: https://doi.org/10.1007/BF03341478

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