Skip to main content
SpringerLink
Log in

Peripheral location of the human late X and homologous association of autosomes numbers one, two and three

  • Published:
Journal of Genetics Aims and scope Submit manuscript

Summary

By application of the “centroid” method of Barton, David and Merrington to a number of H3-thymidine radioautographs, it was determined that the human late-replicatingX chromosome lies towards the periphery of the metaphase in a significant number of cases. Further, in agreement with earlier findings by other authors, the centromeres of chromosomes 1, 2 and 3 were found to lie closer together than is to be expected on a random hypothesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Barton, D. E. And David, F. N. (1962). The analysis of chromosome patterns in the normal cell.Ann. Hum. Genet.,25, 323.

    Article  PubMed  CAS  Google Scholar 

  • Barton, D. E., David, F. N. And Merrington, M. (1964). The positions of the sex chromosomes in the human cell in mitosis.Ann. Hum. Genet.,28, 123.

    Article  PubMed  CAS  Google Scholar 

  • Barton, D. E., David, F. N. And Merrington, M. (1965). The relative positions of the chromosomes in the human cell in mitosis.Ann. Hum. Genet.,29, 139.

    Article  PubMed  CAS  Google Scholar 

  • Barton, D. E., David, F. N., Fix, E. And Merrington, M. (1967). A review of analysis of karyographs of the human cell in mitosisin Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, L. Lecam and J. Neyman, Eds., University of California Press, Berkeley and Los Angeles,5, 349.

    Google Scholar 

  • Chandra, H. S. And Hungerford, D. A. (1967). Identification of the human X chromosome: A reconciliation between results obtained from morphological and from radioautographic studies.Ann. Genet.,10, 13.

    PubMed  CAS  Google Scholar 

  • Mendelsohn, M. L., Conway, T. J., Hungerford, D. A., Kolman, W. A., Perry, B. H. And Prewitt J. M.S. (1966). Computer-oriented analysis of human chromosomes. I. Photometric estimation of DNA content.Cytogenetics,5, 223.

    Article  PubMed  CAS  Google Scholar 

  • Miller, O. J., Mukherjee, B. B., Breg, W. R. And Gamble, A. V. N. (1963). Non-random distribution of chromosomes in metaphase figures from cultured human leucocytes. I. The peripheral location of the Y chromosome.Cytogenetics,2, 1.

    Article  Google Scholar 

  • Morishima, A., Grumbach, M. M. And Taylor, J. H. (1962). Asynchronous duplication of human chromosomes and the origin of sex cliromatin.Proc. Nat. Acad. Sci. (U.S.),48, 756.

    Article  CAS  Google Scholar 

  • Ockey, C. H. (1969). The position of chromosomes at metaphase in human fibroblasts and their DNA synthesis behaviour.Chromosoma,27, 308.

    Article  PubMed  CAS  Google Scholar 

  • Schneiderman, L. J. And Smith, C. A. B. (1962). Non-random distribution of certain homolaegous pairs of normal human chromosomes in metaphase.Nature,195, 1229.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Genetic Studies, 230 Twelfth Cross, Wilson Gardens, Bangalore-27, India

    H. Sharat Chandra & A. K. Anantha Narayana

  2. Indian Statistical Institute, Bangalore-25

    V. V. Buche

  3. The Institute for Cancer Research, 7701, Burholme Avenue, Fox Chase, 19111, Philadelphia, Pennsylvania, USA

    D. A. Hungerford

Authors
  1. H. Sharat Chandra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. K. Anantha Narayana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Buche
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. A. Hungerford
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by grants from the World Health Organization, the Indian National Science Academy, grants CA-05903 (now GM-17551) and CA-06927 from the National Cancer Institute, U.S. Public Health Service, and by an appropriation from the Commonwealth of Pennsylvania.

This paper is dedicated to the late Jack Schultz, who to our knowledge was the first to have recognized the phenomenon of scmatic association in human cells. Two of us (H. S. C. and D.A.H.) remain personally indebted to him for sound guidance, generously given, over an interval of many years.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chandra, H.S., Narayana, A.K.A., Buche, V.V. et al. Peripheral location of the human late X and homologous association of autosomes numbers one, two and three. J Genet 61, 78–83 (1972). https://doi.org/10.1007/BF02984102

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02984102

Keywords

Search

Navigation