Abstract
Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product,erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, (±)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds1 and2 exhibited QR inducing activity, with observed CD (concentration required to double induction) values of 16.7 and 16.4 μM, respectively.
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Jang, D.S., Park, E.J., Kang, YH. et al. Phenolic compounds obtained from stems ofcouepia ulei with the potential to induce quinone reductase. Arch Pharm Res 27, 169–172 (2004). https://doi.org/10.1007/BF02980101
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DOI: https://doi.org/10.1007/BF02980101