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Cytokine secretion patterns and cross-regulation of T cell subsets

  • T Cell Subsets
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Conclusion

The cross-inhibition of TH1 and TH2 cells by IFN-γ and IL-10 may account for at least part of the mutually exclusive regulation of DTH and antibody (especially DTH) responses. It is likely that other cross-regulatory molecules exist, and we know very little about the regulation of the additional cytokine secretion phenotypes described above. In addition, the signals that induce preferential differentiation into a particular cytokine secretion phenotype are not yet understood, although it appears likely that this process is controlled by antigen-presenting cells and cytokines. Given the importance to the host of choosing the appropriate pattern of effector functions, it is likely that the full regulatory pathways of T cell differentiation and cross-regulation will be under precise and complex control.

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  1. Department of Immunology, University of Alberta, Room 865 Medical Sciences Building, T6G 2H7, Edmonton, Alta., (Canada)

    Tim R. Mosmann

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Mosmann, T.R. Cytokine secretion patterns and cross-regulation of T cell subsets. Immunol Res 10, 183–188 (1991). https://doi.org/10.1007/BF02919690

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