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The CD94/NKG2 C-type lectin receptor complex

Involvement in NK Cell-Mediated Recognition of HLA Class I Molecules

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Abstract

A multigene family of human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family. By functional criteria, the CD94/ NKG2-A (kp43) receptor complex appears also involved in NK cell-mediated recognition of different HLA class I allotypes. Similarly to the other NK inhibitory receptors, NKG2-A contains cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). By contrast, NK clones bearing a different receptor complex (CD94/ p39) are triggered upon ligation by CD94-specific monoclonal antibodies (MAbs); the p39 subunit is likely encoded by other member(s) of the NKG2 family. Expression of the different CD94/ NKG2 complexes is warranted to precisely assess their specific interaction with HLA class I molecules, and the molecular basis for their divergent functional properties.

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Authors and Affiliations

  1. Hospital de la Princesa, Universidad Autónoma de Madrid, Spain

    Miguel López-Botet, Marta Carretero, Juan J. Pérez-Villar, Teresa Bellón, Manuel Llano & Francisco Navarro

  2. Servicio de Inmunología Hospital, de la Princesa Diego de León, 62 28006, Madrid, Spain

    Miguel López-Botet

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  1. Miguel López-Botet
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  2. Marta Carretero
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  3. Juan J. Pérez-Villar
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  4. Teresa Bellón
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  5. Manuel Llano
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  6. Francisco Navarro
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Correspondence to Miguel López-Botet.

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López-Botet, M., Carretero, M., Pérez-Villar, J.J. et al. The CD94/NKG2 C-type lectin receptor complex. Immunol Res 16, 175–185 (1997). https://doi.org/10.1007/BF02786361

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