Abstract
After activation, CD4 helper T (Th) cells differentiate into Th1 or Th2 effector cells. These two subsets produce distinct profiles of cytokines and regulate different immune responses. Here we discuss transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression, cell proliferation and apoptosis.
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00011-012-0525-8
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Flavell, R.A., Dong, C. & Davis, R.J. Signaling and cell death in lymphocytes. Inflamm Res 51, 80–82 (2002). https://doi.org/10.1007/BF02684006
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DOI: https://doi.org/10.1007/BF02684006