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Novel revascularization therapies — TMLR and growth factor-induced angiogenesis monitored with cardiac MRI

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4. Summary

Employment of cardiac MRI techniques (cine MRI, wall thickening analysis, quantitative MRFPP, MR tissue tagging) allowed non-invasive localization and assessment of early and late changes in myocardial function and perfusion produced by these new approaches of myocardial revascularization. With its precision in assessment of myocardial perfusion and collateral-dependent territories, cardiac MRI techniques may be of excellent use for the evaluation of effects on myocardial function and perfusion as well as longitudinal outcomes in clinical trials with TMLR and angiogenesis therapies in patients with CAD. As growth factor therapies approach phase III clinical trials, such vital questions as the most effective delivery system, dosages and techniques used for treatment-monitoring parameters remain unanswered. In addition, better definitions of patient selection criteria for TMLR and angiogenesis therapies for both short- and long-term maximum benefits are needed at this time. Large-scale clinical trials with cardiac MRI techniques are needed to reliably assess functional and perfusion reserves of the myocardium pre and post TMLR and angiogenesis therapies. MR-based outcome parameters may aid in answering questions pertinent to the new revascularization treatments.

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Authors and Affiliations

  1. Cardiovascular MRI Section and Core Laboratory, Department of Radiology, University of Minnesota Medical School, 420 Delaware Street SE, B-226 Mayo Memorial, UMHC Box 292, 55455, Minneapolis, MN, USA

    Norbert M. Wilke, Andrey Zenovich, Olaf Muehling & Michael Jerosch-Herold

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  1. Norbert M. Wilke
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  2. Andrey Zenovich
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  3. Olaf Muehling
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  4. Michael Jerosch-Herold
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Correspondence to Norbert M. Wilke.

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Wilke, N.M., Zenovich, A., Muehling, O. et al. Novel revascularization therapies — TMLR and growth factor-induced angiogenesis monitored with cardiac MRI. MAGMA 11, 61–64 (2000). https://doi.org/10.1007/BF02678497

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  • DOI: https://doi.org/10.1007/BF02678497

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