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The MRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes

  • Growth, Differentiation, And Senescence
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Summary

The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10−8 M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.

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Authors and Affiliations

  1. Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine and Boston City Hospital, 80 East Concord Street, M-1013, 02118, Boston, Massachusetts

    Nancy M. Hanafin, Kelly Scott Persons & Michael F. Holick

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  1. Nancy M. Hanafin
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  2. Kelly Scott Persons
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  3. Michael F. Holick
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Hanafin, N.M., Persons, K.S. & Holick, M.F. The MRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes. In Vitro Cell Dev Biol - Animal 30, 187–191 (1994). https://doi.org/10.1007/BF02631442

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  • DOI: https://doi.org/10.1007/BF02631442

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