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The evolution of analysis in life science research and molecular medicine: The potential role of separations

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The Review considers the current state and possible future of separation methods in the rapidly developing field of bioscience. For example, drug development by combinatorial methods allow the synthesis of more than 103 compounds per day and it is clear that the analysis of such large numbers of samples will need a radically new approach in which the technology developed for the etching of integrated electronic circuits is likely to play a major role. An alternative possibility is the development of multiple analyses with parallel bundles of open tubular columns. There are many practical problems to be overcome but it is probable that chromatographic and electrophoresis methods coupled with mass spectrometry will figure prominently until such time as miniaturisation at a molecular level using nanotubes becomes a reality.

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  1. Department of Chemistry, Purdue University, 47907, Lafayette, IN, USA

    F. Regnier

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Regnier, F. The evolution of analysis in life science research and molecular medicine: The potential role of separations. Chromatographia 49 (Suppl 1), S56–S64 (1999). https://doi.org/10.1007/BF02468977

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