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Neuron discharges in the rat auditory cortex during electrical intracortical stimulation

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Abstract

Studies were carried out in rats anesthetized with ketamine or nembutal, with recording of multicellular activity (with separate identification of responses from individual neurons) in the primary auditory cortex before and after electrical intracortical microstimulation. These experiments showed that about half of the set of neurons studied produced responses to short tonal bursts, these responses having two components—initial discharges arising in response to the sound, and afterdischarge occurring after pauses of 50–100 msec. Afterdischarges lasted at least several seconds, and were generally characterized by a rhythmic structure (with a frequency of 8–12 Hz). After electrical microstimulation, the level of spike activity increased, especially in afterdischarges, and this increase could last up to 4 h. Combined peristimulus histograms, cross-correlations, and gravitational analyses were used to demonstrate interactions of neurons, which increased after electrical stimulation and were especially pronounced in the response afterdischarges.

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Authors
  1. P. E. Maldonado
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  2. J. A. Altman
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  3. G. L. Gerstein
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Additional information

Department of Neurosciences, Faculty of Medicine, University of Pennsylvania, Philadelphia, USA. Laboratory of Auditory Physiology, I. P. Pavlov Institute of Physiology, 6 Makarov Bank, 199034 St. Petersburg, Russia. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 82, No. 5-6, pp. 3–17, May–June, 1996.

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Maldonado, P.E., Altman, J.A. & Gerstein, G.L. Neuron discharges in the rat auditory cortex during electrical intracortical stimulation. Neurosci Behav Physiol 28, 48–59 (1998). https://doi.org/10.1007/BF02461912

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  • DOI: https://doi.org/10.1007/BF02461912

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