Abstract
The interaction between the effects of chronic electrical tail shock and clomipramine (CMI) on exploratory activity, behavioral despair and pituitary-adrenal function was studied in adult male rats. Both CMI and shock administered alone significantly reduced exploratory activity in a novel environment (holeboard). Neither interaction nor additive effects were observed when the two treatments were combined. In contrast, chronic shock increased the immobility in the forced swimming test (behavioral despair) and this effect was completely prevented by concomitant CMI administration. Pituitary-adrenal function was not significantly influenced by any of the treatments. The results indicate that: (a) chronic CMI treatment prevented some but not all behavioral changes caused by chronic shock, and (b) no interaction with basal and stress levels of pituitary-adrenal hormones was observed.
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References
Armario A, Castellanos JM (1984) A simple procedure for direct corticosterone radioimmunoassay in the rat. Rev Exp Fisiol 40:437–443
Armario A, Castellanos JM, Balasch J (1984) Effect of crowding on emotional reactivity in male rats. Neuroendocrinology 39:330–333
Armario A, Restrepo C, Castellanos JM, Balasch J (1985) Dissociation between adrenocorticotropin and corticosterone responses to restraint stress after previous chronic exposure to stress. Life Sci 36:2085–2092
Blavet N, DeFeudis FV (1982) Inhibition of food intake in the rat by antidepressants. Pharmacol Res Commun 14:663–669
Broitman ST, Donoso AO (1978) Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development. Psychopharmacology 56:93–101
File SE, Tucker JC (1986) Behavioral consequences of antidepressant treatment in rodents. Neurosci Biobehav Rev 10:123–134
File SE, Wardill AG (1975) Validity of head-dipping as a measure of exploration in a modified holeboard. Psychopharmacologia 44:53–59
Fuxe K, Ogren SO, Everitt BJ, Agnati LP, Eneroth P, Gustafsson JA, Jonsson G, Skett P, Holm AC (1978) The effect of antidepressant drugs of the imipramine type on various monoamine systems and their relation to changes in behaviour and neuroendocrine function. In: Garattini S (ed) Depressive disorders. Schattauer, New York Stuttgart, pp 64–97
García-Marquez C, Armario A (1987) Chronic stress depresses exploratory activity and behavioral performance in the forced swimming test without altering ACTH response to a novel acute stressor. Physiol Behav (in press)
Kendall DA, Duman R, Slopis J, Enna SJ (1982) The influence of ACTH and yohimbine on antidepressant-induced declines in rat brain neurotransmitter receptor binding and function. J Pharmacol Exp Ther 222:566–571
Laakmann G, Wittmann M, Gugath M, Mueller OA, Treusch J, Wahlster U, Stalla GK (1984) Effects of psychotropic drugs (desimipramine, chlorimipramine, sulpiride and diazepam) on the human HPA axis. Psychopharmacology 84:66–70
Laakmann G, Schoen HW, Blaschke D, Wittmann M (1985) Dosedependent growth hormone, prolactin and cortisol stimulation after i.v. administration of desimipramine in human subjects. Psychoneuroendocrinology 10:83–93
Levine S, Madden IV J, Conner RL, Moskal JR, Anderson C (1973) Physiological and behavioral effects of prior aversive stimulation (preshock) in the rat. Physiol Behav 10:467–471
Platt JE, Stone EA (1982) Chronic restraint stress elicits a positive antidepressant response on the forced swimming test. Eur J Pharmacol 82:179–181
Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391
Rodriguez-Echandia EL, Broitman ST, Foscolo MR (1982) Chronic treatment with therapeutic doses of chlorimipramine causes hyperactivity in male rats. IRCS Med Sci 10:366–367
Stone EA (1983) Adaptation to stress and brain adrenergic receptors. Neurosci Biobehav Rev 7:503–509
Stone EA (1985) Problems with current catecholamine hypotheses of antidepressants agents: speculations leading to a new hypothesis. Behav Brain Sci 6:535–577
Stone EA, Platt JE (1982) Brain adrenergic receptors and resistance to stress. Brain Res 237:405–414
Stone EA, Trullas R, Platt JE (1984) The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 8:587–592
Stone EA, Slucky AV, Platt JE, Trullas R (1985) Reduction of the cyclic adenosine 3′, 5′-monophosphate response to catecholamines in rat brain slices after repeated restraint stress. J Pharmacol Exp Ther 233:382–388
Stricker EM (1983) Brain neurochemistry and the control of food intake. In: Satinoff E, Teiltelbaum P (eds). Handbook of behavioral neurobiology, vol VI: motivation. Plenum, New York, pp 329–366
Sulser F, Janowsky A, Okada F, Manier DH, Mobley PL (1983) Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression. Neuropharmacology 22:425–431
Tucker JC, File SE (1986) The effects of tricyclic and “atypical” antidepressants on spontaneous locomotor activity in rodents. Neurosci Biobehav Rev 10:115–121
Vogel GW, Minter K, Woolwine B (1986) Effects of chronically administered antidepressant drugs on animal behavior. Physiol Behav 36:659–666
Weiss JM, Goodman PA, Losito BG, Corrigan S, Charry JM, Bailey WH (1981) Behavioral depression produced by an uncontrollable stressor: relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain. Brain Res Rev 3:167–205
Willner P (1984) The validity of animal models of depression. Psychopharmacology 83:1–16
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García-Marquez, C., Armario, A. Interaction between chronic stress and clomipramine treatment in rats. Effects on exploratory activity, behavioral despair, and pituitary-adrenal function. Psychopharmacology 93, 77–81 (1987). https://doi.org/10.1007/BF02439590
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DOI: https://doi.org/10.1007/BF02439590