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The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins

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Abstract

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growth and survival of neurons in the central and peripheral nervous systems. Each of these proteins bind to at least two membrane receptors. One is the low affinity nerve growth factor receptor (p75), which binds each member of the neurotrophin family. The other is one of a family of tyrosine kinase receptors —trkA binds only NGF, the relatedtrkB receptor binds BDNF and NT-3, andtrkC binds NT-3 alone. This article reviews kinetic and biochemical information on p75 and its relationship to thetrk gene products.

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  1. Philip A. Barker

    Present address: Department of Neurobiology Stanford University School of Medicine Stanford, California, USA

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  1. Department of Anatomy and Cell Biology, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada

    Philip A. Barker & Richard A. Murphy

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Barker, P.A., Murphy, R.A. The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins. Mol Cell Biochem 110, 1–15 (1992). https://doi.org/10.1007/BF02385000

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