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Genetic analysis of cholinergic nerve terminal function in invertebrates

  • Published:
Journal of Neurocytology

Summary

Genetic analysis of nerve terminal function is proving fruitful and studies on invertebrates are making a substantial impact. In this survey, particular emphasis has been placed on cholinergic chemical synaptic transmission. The advanced genetics ofDrosophila melanogaster andCaenorhabditis elegans with their rich diversity of behavioural and biochemical mutants is providing new insights into the functions of key molecular components of synapses. A ‘space-invader’ mutant ofPeriplaneta americana permits investigations of competition between neurons during synaptogenesis and its impact on neurotransmitter release. The growing importance of theC. elegans genome as a major research resource is emphasized in this survey.

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  1. The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK

    Howard A. Baylis & David B. Sattelle

  2. Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK

    Nancy J. Lane

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Baylis, H.A., Sattelle, D.B. & Lane, N.J. Genetic analysis of cholinergic nerve terminal function in invertebrates. J Neurocytol 25, 747–762 (1996). https://doi.org/10.1007/BF02284839

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