Abstract
The serotonergic agonists fenfluramine and fluoxetine and the catecholaminergic agonists amphetamine and phenylpropanolamine are well known to cause a reduction in intake in rats. In the studies reported here we investigated the effects of these drugs on the microstructure of licking behavior of the rat ingesting 0.4 M sucrose. The purpose was to examine the similarities in the behavioral effects within and between these two classes of anorectic agents. The serotonergic agonists fenfluramine and fluoxetine caused a reduction in intake primarily by reducing the size of bursts and clusters of licking within the test meal without affecting the duration of the meal, suggesting a reduction in the palatability of the test solution. The catecholamine agonists amphetamine and phenylpropanolamine reduced intake primarily by reducing the number of bursts and clusters without affecting their size, suggesting a fractionation in the organization of the normal pattern of ingestion. The differences between the two serotonin and the two catecholamine agonists on the microstructure of the licking behavior suggest a different effect of the two neurotransmitters on the motor system that controls ingestive behavior. The similarities between the two different agonists within each class suggests a common neurotransmitter mechanism responsible for these two different effects on the behavior of the animals.
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References
Antelman SM, Rowland N, Kocan C (1981) Lack of cross tolerance among serotonergic drugs and sensitization of amphetamine's effect. In: Garattini S, Samanin R (eds) Anorectic agents: mechanisms of action and tolerance. Raven Press, New York, pp 45–62
Blundell JE (1987) Structure, process, and mechanism: case studies in the psychopharmacology of feeding. In: Iverson LL, Iverson SD, Snyder SH (eds) Handbook of psychopharmacology. Plenum Press, New York
Blundell JE, Latham CJ (1978) Pharmacological manipulation of feeding behavior: possible influences of serotonin and dopamine on food intake. In: Garattini S, Samanin R (eds) Central mechanisms of anorectic drugs. Raven Press, New York, pp 83–109
Blundell JE, Latham CJ, Leshem MB (1976) Differences between the anorexic actions of amphetamine and fenfluramine — possible effects on hunger and satiety. J Pharmacol Psychopharmacol 28:471–477
Burton MJ, Cooper SJ, Popplewell DA (1981) The effect of fenfluramine on the microstructure of feeding and drinking in the rat. Br J Pharmacol 72:621–633
Carruba MO, Ricciardi S, Spano P, Mantegazza P (1985) Dopaminergic and serotonergic anorectics differentially antagonize insulin- and 2DG-induced hyperphagia. Life Sci 36:1739–1749
Davis JD (1989) The microstructure of ingestive behavior. Ann My Acad Sci 575:106–121
Davis JD (1990) Quick Lick [Computer program] Available from DiLog Instruments, 3124 Ortega Dr. Tallahassee, FL, 32312
Davis JD, Levine M (1977) A model for the control of ingestion. Psychol Rev 89:379–412
Davis JD, Smith GP (1992) Analysis of microstructure of the rhythmic tongue movements of rats ingesting maltose and sucrose solutions. Behav Neurosci 106:217–228
Eisenberg MS, Maher TJ, Silverman HI (1987) A comparison of the effects of phenylpropanolamine,d-amphetamine andd-norpseudoephedrine on open-field locomotion and food intake in the rat. Appetite 9:31–37
Fuller RW, Wong DT (1989) Fluoxetine: a serotonergic appetite suppressant drug. Drug Dev Res 17:1–15
Goudie AJ, Thornton EW, Wheeler TJ (1976) Effect of Lilly 110140, a specific inhibitor of 5-hydroxytryptophan uptake, on food intake and on 5-hydroxytryptophan-induced anorexia. J Pharm Pharmacol 28:318–320
Grill HJ, Norgren R (1978) Taste reactivity test: I. Mimetic responses to gustatory stimuli in neurological normal rats. Brain Res 143:263–279
Henderson R (1990) Contact 104/108 Lickometer, Di Log Instruments & Systems, 3124 Ortega Dr. Tallahassee, FL, 32312
Hsiao S, Spencer R (1983) Analysis of the licking response in rats: Effects of cholecystokinin and bombesin. Behav Neurosci 91:234–245
Knowler WC, Ukena ET (1973) The effect of chlorpromazine, pentobarbital, chlordiazepoxide andd-amphetamine on rates of licking in the rat. J Pharmacol Exp Ther 184:385–397
Montgomery MJ, Burton MJ (1986) Effects of peripheral 5-HT on consumption of flavored solutions. Psychopharmacology 88:262–266
Montgomery AMJ, Willner P (1988) Fenfluramine disrupts the behavioral satiety sequence in rats. Psychopharmacology 94:397–401
Neil JC, Cooper SJ (1989) Effects of 5-hydroxytryptamine andd-fenfluramine on sham feeding and sham drinking in the gastric fistulated rat. Physiol Behav 46:949–953
Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS (1975) Fenfluramine: a review of its pharmacological properties and therapeutic effects in obesity. Drugs 10:241–323
Schneider LH, Davis JD, Watson CA, Smith GP (1990) Similar effect of raclopride and reduced sucrose concentration on the microstructure of sucrose sham feeding. Eur J Pharmacol 186:61–70
Wellman PJ (1990) A review of the physiological bases of the anorectic action of phenylpropanolamine (d, 1-norephedrine). Neurosci Biobehav Rev 14:339–355
Wellman PJ, Cockroft R (1986) Effects of amphetamine and phenylpropanolamine on latency to feed and cumulative liquid diet intake in rats. Pharmacol Biochem Behav 32:147–150
Wiesenfeld ZB, Halperin P, Tapper DN (1977) Licking behavior: evidence of a hypoglossal oscillator. Science 196:1122–1124
Wilkinson L (1990) SYSTAT 5.0, The system for statistics [Computer program]. Systat Evanston IL
Willner P, McGuirk J, Phillips G, Muscat R (1990) Behavioural analysis of the anorectic effect of fluoxetine and fenfluramine Psychopharmacology 102:273–277
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Supported by NIH Grant DK41563 (JDD).
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Asin, K.E., Davis, J.D. & Bednarz, L. Differential effects of serotonergic and catecholaminergic drugs on ingestive behavior. Psychopharmacology 109, 415–421 (1992). https://doi.org/10.1007/BF02247717
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DOI: https://doi.org/10.1007/BF02247717