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Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the Pavlovian conditioned response

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Abstract

Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kgd-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the amphetamine-induced response was attenuated by both a D-1 (SCH 23390) and a D-2 (metoclopramide) antagonist, sensitization to amphetamine was attenuated by the D-1 antagonist only. In addition, expression of a placebo-like response observed on day 4 (characterized previously as a Pavlovian conditioned response) was attenuated by both the D-1 and D-2 antagonists without disrupting extinction of the response.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Albany Medical College, 47 New Scotland Avenue, 12208, Albany, NY, USA

    Kelly L. Drew & Stanley D. Glick

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  1. Kelly L. Drew
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  2. Stanley D. Glick
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Drew, K.L., Glick, S.D. Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the Pavlovian conditioned response. Psychopharmacology 101, 465–471 (1990). https://doi.org/10.1007/BF02244223

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  • DOI: https://doi.org/10.1007/BF02244223

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