Summary
To determine whether the colonic transit accelerating effect of (−)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.) was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.
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Krevsky, B., Fisher, R.S. & Cowan, A. Failure of (+)-naloxone to accelerate feline colonic transit. Experientia 46, 217–219 (1990). https://doi.org/10.1007/BF02027320
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DOI: https://doi.org/10.1007/BF02027320