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Comparison of the blocking potency of local anesthetics applied at different pH values

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Zusammenfassung

Es wird die Annahme gestützt, dass in der Nervenmembran die aktive Form lokal anaesthetischer Mittel die ionisierte Form ist. Die das Wirkungspotential herabserzende Wirkung dieser Stoffe scheint durch die höheren Konzentrationen der nicht-ionisierten Form bedingt zu sein.

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References

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Author notes

  1. K. Murayama

    Present address: Department of Physiology, Kyoto Prefectural University of Medicine, Nishigin, Kyoto, Japan

Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Kentucky, 40506, Lexington, Kentucky, USA

    D. T. Frazier, K. Murayama & T. Narahashi

  2. Department of Physiology and Pharmacology, Duke University Medical Center, 27706, Durham, North Carolina, USA

    D. T. Frazier, K. Murayama & T. Narahashi

Authors
  1. D. T. Frazier
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  2. K. Murayama
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  3. T. Narahashi
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Frazier, D.T., Murayama, K. & Narahashi, T. Comparison of the blocking potency of local anesthetics applied at different pH values. Experientia 28, 419–420 (1972). https://doi.org/10.1007/BF02008313

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