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Killing kinetics of five orally administered antibiotics at clinically achievable concentrations againstmoraxella catarrhalis

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Abstract

Time-kill kinetic studies were used to measure the bactericidal activity of amoxicillin/clavulanic acid (in a new form for pediatric use), cefaclor, cefuroxime, cefixime and erythromycin against 30 beta-lactamase producingMoraxella catarrhalis strains. Antibiotics were tested at the mean maximum serum concentration observed after administration of a standard dose and at 0.5 × Cmax, 0.33 × Cmax and 0.25 × Cmax. A 2 log10 reduction in colony counts was obtained with the Cmax of amoxicillin/clavulanic acid and cefixime after 5 h of incubation. After 24 h of incubation a decrease of 3 and 4 log was observed with cefixime and amoxicillin/clavulanic acid respectively. At 0.5 × Cmax and 0.33 × Cmax, bactericidal activity was obtained only with amoxicillin/clavulanic acid.

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Authors and Affiliations

  1. Service de Microbiologie, Hôpital Robert Debré, 48 Boulevard Sérurier, 75935, Paris Cedex 19, France

    E. Bingen, F. Bourgeois, C. Doit & N. Lambert-Zechovsky

  2. Laboratoire de Bactériologie, Centre Hospitalier, Aixen-Provence, France

    H. Chardon

Authors
  1. E. Bingen
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  2. F. Bourgeois
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  3. H. Chardon
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  4. C. Doit
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  5. N. Lambert-Zechovsky
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Bingen, E., Bourgeois, F., Chardon, H. et al. Killing kinetics of five orally administered antibiotics at clinically achievable concentrations againstmoraxella catarrhalis . Eur. J. Clin. Microbiol. Infect. Dis. 11, 923–926 (1992). https://doi.org/10.1007/BF01962375

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  • DOI: https://doi.org/10.1007/BF01962375

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